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A computational investigation of electrotonic coupling between pyramidal cells in the cortex

机译：皮质锥体桥质电偶联的计算研究

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The existence of electrical communication among pyramidal cells (PCs) in the adult cortex has been debated by neuroscientists for several decades. Gap junctions (GJs) among cortical interneurons have been well documented experimentally and their functional roles have been proposed by both computational neuroscientists and experimentalists alike. Experimental evidence for similar junctions among pyramidal cells in the cortex, however, has remained elusive due to the apparent rarity of these couplings among neurons. In this work, we develop a neuronal network model that includes observed probabilities and strengths of electrotonic coupling between PCs and gap-junction coupling among interneurons, in addition to realistic synaptic connectivity among both populations. We use this network model to investigate the effect of electrotonic coupling between PCs on network behavior with the goal of theoretically addressing this controversy of existence and purpose of electrotonically coupled PCs in the cortex.
机译：成人皮质中的金字塔细胞（PC）之间的电信通信已经被神经科学家争论了几十年。皮质联系（GJS）在实验上进行了很好的记录，并通过计算神经科学家和实验主义者提出了其功能作用。然而，由于神经元中这些联轴器的表观罕见，皮质中锥体细胞中类似连接的实验证据仍然难以难以实现。在这项工作中，我们开发了一个神经元网络模型，其包括观察到在整个群体中的现实突触连接之外的PC和间隙接合耦合之间的电偶联耦合的概率和强度。我们使用该网络模型来研究PC之间电耦合对网络行为的影响，从理论上解决了皮质中电耦合PC的存在和目的的存在和目的的目标。

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