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首页> 外文期刊>Journal of Computational Neuroscience >Dysfunctional mode switching between fixation and saccades: collaborative insights into two unusual clinical disorders
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Dysfunctional mode switching between fixation and saccades: collaborative insights into two unusual clinical disorders

机译：固定和扫描之间的功能失调模式切换：对两个不寻常的临床疾病的合作见解

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摘要

Voluntary rapid eye movements (saccades) redirect the fovea toward objects of visual interest. The saccadic system can be considered as a dual-mode system: in one mode the eye is fixating, in the other it is making a saccade. In this review, we consider two examples of dysfunctional saccades, interrupted saccades in late-onset Tay-Sachs disease and gaze-position dependent opsoclonus after concussion, which fail to properly shift between fixation and saccade modes. Insights and benefits gained from bi-directional collaborative exchange between clinical and basic scientists are emphasized. In the case of interrupted saccades, existing mathematical models were sufficiently detailed to provide support for the cause of interrupted saccades. In the case of gaze-position dependent opsoclonus, existing models could not explain the behavior, but further development provided a reasonable hypothesis for the mechanism underlying the behavior. Collaboration between clinical and basic science is a rich source of progress for developing biologically plausible models and understanding neurological disease. Approaching a clinical problem with a specific hypothesis (model) in mind often prompts new experimental tests and provides insights into basic mechanisms.
机译：自愿快速眼动（扫视）将Fovea重定向到视觉兴趣的对象。扫视系统可以被认为是双模系统：在一个模式中，眼睛固定，另一个模拟，另一方面，在另一个模式下，它正在制作扫视。在这篇综述中，我们考虑了两个功能失调扫描的例子，在脑震荡之后中断疾病疾病和凝视定位依赖性Ophsoclonus中断的囊肿，这不能在固定和扫视模式之间恰当地移位。强调临床和基础科学家之间的双向协作交流中获得的见解和益处。在中断扫描的情况下，现有的数学模型足以提供对中断扫描的原因的支持。在凝视定位依赖的Ophsoclonus的情况下，现有模型无法解释行为，而且进一步的发展为行为的机制提供了合理的假设。临床和基础科学之间的合作是发展生物合理的模型和了解神经疾病的丰富进步。接近具有特定假设（模型）的临床问题经常促使新的实验测试并向基本机制提供见解。

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  • 来源
    《Journal of Computational Neuroscience》 |2021年第3期|283-293|共11页
  • 作者

    Rucker Janet C.; Rizzo John-Ross; Hudson Todd E.; Horn Anja K. E.; Buettner-Ennever Jean A.; Leigh R. John; Optican Lance M.;

  • 作者单位

    NYU Grossman Sch Med Dept Neurol New York NY 10016 USA|NYU Dept Ophthalmol Grossman Sch Med 550 1St Ave New York NY 10016 USA;

    NYU Grossman Sch Med Dept Neurol New York NY 10016 USA|NYU Grossman Sch Med Dept Rehabil Med New York NY USA|NYU Tandon Sch Engn Dept Biomed Engn New York NY USA|NYU Tandon Sch Engn Dept Mech Engn New York NY USA|NYU Tandon Sch Engn Dept Aerosp Engn New York NY USA;

    NYU Grossman Sch Med Dept Neurol New York NY 10016 USA|NYU Grossman Sch Med Dept Rehabil Med New York NY USA;

    Ludwig Maximilians Univ Munchen Dept Anat & Cell Biol 1 Munich Germany;

    Ludwig Maximilians Univ Munchen Dept Anat & Cell Biol 1 Munich Germany;

    Case Western Reserve Univ Dept Neurol Cleveland OH 44106 USA;

    NEI Lab Sensorimotor Res DHHS NIH Bethesda MD 20892 USA;

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  • 正文语种 eng
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  • 关键词

    Saccade termination; Late-onset Tay Sachs; Concussion; Opsoclonus; Eye position-dependence;

    机译：Saccade终止;晚期陈图SACH;震荡;Opsoclonus;眼睛位置依赖;

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