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首页> 外文期刊>Journal of Computational Neuroscience >Gabapentin and memantine increases randomness of oscillatory waveform in ocular palatal tremor
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Gabapentin and memantine increases randomness of oscillatory waveform in ocular palatal tremor

机译：加巴亨坦和Memantine增加了眼睛腭震颤中振荡波形的随机性

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摘要

Syndrome of oculopalatal tremor (OPT) causes pendular nystagmus of the eyes and its disabling consequence on the visual system. Classic pharmacotherapeutic studies revealed reduction in the eye velocity of the oscillatory waveforms. Subjective improvement in vision, however, remains out of proportionately low. Elegant models depicting quasi-sinusoidal coarse oscillations of the eyes highlighted two distinct oscillators; one at the inferior olive causing primary 2 Hz oscillations, while the second, independent oscillator, at the cerebellum adding the randomness to the waveform. Here we examined whether pharmacotherapy affects the randomness of the oscillatory waveform. Horizontal, vertical, and torsional angular eye positions were measured independently from both eyes as six subjects with OPT directed gaze toward a straight-ahead target. The measurements were performed before administration of alpha-2-delta calcium channel blocker (gabapentin) or NMDA receptor antagonist (memantine) and after the subjects were treated with each of these drugs for at least 8 days. Amplitude and velocity of eye oscillations were reduced by gabapentin and memantine, but there was an increase in the waveform randomness. We found that the increase in randomness was proportionate to the amount of reduction in the waveform velocity or amplitude. Hierarchical clustering revealed distinct patterns of oscillatory waveforms, with each subject belonging to a specific cluster group. The pharmacotherapy changed the waveform clustering pattern of the waveform in each subject. We conclude that in addition to incomplete resolution of the oscillation intensity, increased randomness could be one of the reasons why there is not enough clinical difference in the patients' visual quality.
机译：oculopalatal震颤综合征（opt）导致眼睛的眼睛囊臂和对视觉系统的禁用后果。经典药物治疗研究揭示了振荡波形的眼睛速度降低。然而，愿景的主观改善仍然是比例低的。典雅的模型描绘了曲线的准正弦粗振荡突出了两个不同的振荡器;一个处于劣橄榄，导致初级2 Hz振荡，而第二独立振荡器，在小脑中增加了波形的随机性。在这里，我们检查了药物治疗是否影响振荡波形的随机性。通过双眼独立地测量水平，垂直和扭转角度位置，作为六个受试者，其中选择朝向前方目标。在施用α-2-Δ钙通道阻断剂（加巴蛋白）或NMDA受体拮抗剂（MEMANTINE）之前进行测量，并在将受试者用这些药物处理至少8天后。通过加巴邦和忆内降低眼睛振荡的幅度和速度，但波形随机性增加。我们发现随机性的增加与波形速度或幅度的降低量成比例。分层聚类显示了振荡波形的不同模式，每个主题属于特定的集群组。药物疗法在每个受试者中改变了波形的波形聚类模式。我们得出结论，除了不完全解决振荡强度之外，随机性增加可能是患者视觉质量没有足够的临床差异的原因之一。

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  • 来源
    《Journal of Computational Neuroscience》 |2021年第3期|319-331|共13页
  • 作者

    Theeranaew Wanchat; Thurtell Matthew J.; Loparo Kenneth; Shaikh Aasef G.;

  • 作者单位

    Louis Stokes Cleveland VA Med Ctr Daroff DellOsso Ocular Motil Lab Cleveland OH 44106 USA|Univ Hosp Dept Neurol 11100 Euclid Ave Cleveland OH 44110 USA|Case Western Reserve Univ Dept Elect Comp & Syst Engn Cleveland OH 44106 USA;

    Univ Iowa Dept Ophthalmol & Visual Sci Iowa City IA USA;

    Case Western Reserve Univ Dept Elect Comp & Syst Engn Cleveland OH 44106 USA;

    Louis Stokes Cleveland VA Med Ctr Daroff DellOsso Ocular Motil Lab Cleveland OH 44106 USA|Univ Hosp Dept Neurol 11100 Euclid Ave Cleveland OH 44110 USA|Case Western Reserve Univ Dept Neurol Cleveland OH 44106 USA|Case Western Reserve Univ Dept Biomed Engn Cleveland OH 44106 USA;

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  • 正文语种 eng
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  • 关键词

    Cerebellum; Calcium channels; Inferior olive; Brain stem; Purkinje neurons;

    机译：小脑;钙通道;劣质橄榄;脑干;Purkinje神经元;

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