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首页> 外文期刊>Journal of Computational Neuroscience >Effects of subthalamic deep brain stimulation on fixational eye movements in Parkinson's disease
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Effects of subthalamic deep brain stimulation on fixational eye movements in Parkinson's disease

机译：亚粒细胞深脑刺激对帕金森病的阴茎眼球运动的影响

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摘要

Miniature yoked eye movements, fixational saccades, are critical to counteract visual fading. Fixational saccades are followed by a return saccades forming squarewaves. Present in healthy states, squarewaves, if too many or too big, affect visual stability. Parkinson's disease (PD), where visual deficits are not uncommon, is associated with the squarewaves that are excessive in number or size. Our working hypothesis is that the basal ganglia are at the epicenter of the abnormal fixational saccades and squarewaves in PD; the effects are manifested through their connections to the superior colliculus (affecting saccade frequency and amplitude) and the cerebellum (affecting velocity and amplitude). We predict that the subthalamic deep brain stimulation (DBS) variably affects the amplitude, frequency, and velocity of fixational saccade and that the effect depends on the electrode's proximity or the volume of activated tissue in the subthalamic nucleus' connections with the superior colliculus or the cerebellum. We found that DBS modulated saccade amplitude, frequency, and velocity in 11 PD patients. Although all three parameters were affected, the extent of the effects varied amongst subjects. The modulation was dependent upon the location and size of the electrically activated volume of the subthalamic region.
机译：微型轭眼球运动，固定扫视对于抵消视觉衰落至关重要。固定扫视之后是形成正方形的返回扫视。存在于健康状态，正方形，如果太多或太大，影响可视稳定性。帕金森病（PD），视觉赤字不罕见，与数量或大小过度过度的平方波有关。我们的工作假设是基础神经节在PD中的异常固定扫视和正方形的震中;这些效果通过它们与上针（影响扫描频率和振幅）和小脑（影响速度和振幅）的连接来表现为。我们预测亚饱和的深脑刺激（DBS）可变地影响固定扫视的幅度，频率和速度，并且效果取决于电极的接近或激活组织中与优越的小学的连接中的活性组织的体积小脑。我们发现，11个PD患者中的DBS调制扫描幅度，频率和速度。尽管所有三个参数都受到影响，但效果的程度在受试者之间变化。调制取决于分离区域的电激活体积的位置和尺寸。

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  • 来源
    《Journal of Computational Neuroscience》 |2021年第3期|345-356|共12页
  • 作者

    Beylergil Sinem Balta; Murray Jordan; Noecker Angela M.; Gupta Palak; Kilbane Camilla; McIntyre Cameron C.; Shaikh Aasef G.; Ghasia Fatema F.;

  • 作者单位

    Case Western Reserve Univ Dept Biomed Engn Cleveland OH 44106 USA|Louis Stokes Cleveland VA Med Ctr Natl VA Parkinson Consortium Ctr Neurol Serv Daroff DellOsso Ocular Motil & Vestibular Lab Cleveland OH 44106 USA;

    Cleveland Clin Cole Eye Inst Cleveland OH 44106 USA;

    Case Western Reserve Univ Dept Biomed Engn Cleveland OH 44106 USA;

    Case Western Reserve Univ Dept Biomed Engn Cleveland OH 44106 USA|Louis Stokes Cleveland VA Med Ctr Natl VA Parkinson Consortium Ctr Neurol Serv Daroff DellOsso Ocular Motil & Vestibular Lab Cleveland OH 44106 USA;

    Case Western Reserve Univ Dept Neurol Cleveland OH 44106 USA|Univ Hosp Movement Disorders Ctr Neurol Inst Cleveland OH 44106 USA;

    Case Western Reserve Univ Dept Biomed Engn Cleveland OH 44106 USA;

    Case Western Reserve Univ Dept Biomed Engn Cleveland OH 44106 USA|Louis Stokes Cleveland VA Med Ctr Natl VA Parkinson Consortium Ctr Neurol Serv Daroff DellOsso Ocular Motil & Vestibular Lab Cleveland OH 44106 USA|Case Western Reserve Univ Dept Neurol Cleveland OH 44106 USA|Univ Hosp Movement Disorders Ctr Neurol Inst Cleveland OH 44106 USA;

    Cleveland Clin Cole Eye Inst Cleveland OH 44106 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Vision; Saccades; Gaze; Cerebellum; Basal ganglia;

    机译：愿景;扫视;凝视;小脑;基础神经节;

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