...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Computational Neuroscience >Frontotemporal dementia patients exhibit deficits in predictive saccades
【24h】

Frontotemporal dementia patients exhibit deficits in predictive saccades

机译：终身痴呆患者在预测扫描中表现出缺陷

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Prediction and time estimation are all but required for motor function in everyday life. In the context of eye movements, for instance, they allow predictive saccades and eye re-acceleration in anticipation of a target re-appearance. While the neural pathways involved are not fully understood, it is known that the frontal lobe plays an important role. As such, neurological disorders that affect it, such as frontotemporal (FTD) dementia, are likely to induce deficits in such movements. In this work, we study the performances of frontotemporal dementia patients in an oculomotor task designed to elicit predictive saccades at different rates, and compare them to young and older adults. Clear deficits in the production of predictive saccades were found in patients, in particular when the time between saccades was short (similar to 500 ms). Furthermore, one asymptomatic C9ORF72 mutation bearer showed patterns of oculomotor behavior similar to FTD patients. He exhibited FTD symptoms within 3 years post-measure, suggesting that an impairment of oculomotor function could be an early clinical sign. Taken together, these results argue in favor of a role of the frontal lobe in predictive movements timing over short timescales, and suggest that predictive saccades in FTD patients warrant further investigation to fully assess their potential as a diagnostic aid.
机译：预测和时间估计全部，而是需要在日常生活中的电机功能所需的。例如，在眼睛运动的背景下，它们允许预测目标重新出现的预测扫描和眼睛重新加速。虽然所涉及的神经途径不完全明白，但是已知额叶发挥着重要作用。因此，影响其的神经系统疾病，例如胎儿（FTD）痴呆，可能在这种运动中诱导缺陷。在这项工作中，我们研究了旨在以不同的速率引出预测性扫描的动声器任务中的终身痴呆症患者的性能，并将它们与年轻人和老年人进行比较。在患者中发现了预测扫描的生产中的清晰缺陷，特别是当扫视之间的时间短（类似于500毫秒）时。此外，一种无症状的C9ORF72突变承载显示出类似于FTD患者的动血管行为模式。他在措施后3年内展出了FTD症状，表明眼动函数的损害可能是早期临床迹象。总之，这些结果有利于额叶在短时间节奏中的预测运动时机的作用，并表明FTD患者的预测扫描旨在进一步调查，以充分评估其作为诊断援助的潜力。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号