A simple modification of the Q-plate for parallel screening and combinatorial crystallization

Enrico A.Sura

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A simple modification of the Q-plate for parallel screening and combinatorial crystallization

机译：Q板的简单修改，可进行平行筛选和组合结晶

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In many cases it can be advantageous to screen crystallization conditions in parallel. Tasks, such as the setting up a standard screen for several proteins simultaneously or analyzing the effect of drop size and different precipitant-protein drop ratios can be done more efficiently when drops are set up in parallel using a common reservoir. However, a real need for parallel screening becomes apparent when analyzing a large number of different complexes of the same protein, or when using methods such as stoichiometry variation screening and other combinatorial crystallization methods.

机译：在许多情况下，平行筛选结晶条件可能是有利的。当使用通用容器并行设置液滴时，可以更高效地完成诸如同时为几种蛋白质建立标准筛选或分析液滴大小和不同沉淀剂-蛋白质液滴比率的影响等任务。但是，当分析大量相同蛋白质的不同复合物时，或使用诸如化学计量比变化筛选和其他组合结晶方法等方法时，对平行筛选的真正需求就变得显而易见。

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来源
《Journal of Crystal Growth》 |2001年第4期|p.545-552|共8页
作者
Enrico A.Sura;
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作者单位

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
原文格式 PDF
正文语种 eng
中图分类晶体学;
关键词
Crystallization screening; Proteins;

机译：结晶筛选;蛋白质类;

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1. Massively Parallel Combinatorial Screening [J] . Diana Hernandez Genetic Engineering & Biotechnology News: The Information Source of the Biotechnology Industry . 2015,第13期

机译：大规模并行组合筛选
2. Massively Parallel Combinatorial Screening [J] . Diana Hernandez Genetic Engineering & Biotechnology News: The Information Source of the Biotechnology Industry . 2015,第13期

机译：大规模并行组合筛选
3. Combinatorial arrays and parallel screening for positive electrode discovery [J] . A.D. Spong, G. Vitins, S. Guerin, Journal of power sources . 2003,第Jun期

机译：组合阵列和平行筛选用于发现正极
4. Modification of natural domains by combinatorial chemistry:a new solid phase based screening test for protein folding detection [C] . Jose J.Pastor, Irene Fernandez, Francesc Rabanal, European Peptide Symposium . 2002

机译：组合化学改性天然域：蛋白质折叠检测的新固相筛选试验
5. Frontiers of Metallic Glass Electrochemistry: Synthesis, Surface Modification and Combinatorial Screening for Energy conversion and Biomedical Applications. [D] . Li, Jinyang. 2017

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6. In Vivo Angiogenesis Screening and Mechanism of Action of Novel Tanshinone Derivatives Produced by One-Pot Combinatorial Modification of Natural Tanshinone Mixture from Salvia Miltiorrhiza [O] . Zhe-Rui Zhang, Jin-Hang Li, Shang Li, -1

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7. Re-profiling of natural inhibitor via combinatorial drug screening: Brefeldin A variant design as an effective antagonist leading to EPAC2 structure modification and antibody design for identification [O] . Akshay Uttarkar, Vidya Niranjan 2021

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8. Beyond Data Parallelism: The Advantages of Multiple Parallelizations in Combinatorial Search. [R] . Crowl, L. A., Crovella, M. E., LeBlanc, T. J., 1993

机译：超越数据并行：组合搜索中多重并行化的优势。

A simple modification of the Q-plate for parallel screening and combinatorial crystallization

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