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首页> 外文期刊>Journal of Crystal Growth >Crystallization behavior of taltirelin polymorphs in a mixture of water and methanol
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Crystallization behavior of taltirelin polymorphs in a mixture of water and methanol

机译：塔替瑞林多晶型物在水和甲醇混合物中的结晶行为

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摘要

Taltirelin, a central nervous system activating agent, has two crystal forms (α- and β-forms). The solvent effect on the crystallization behavior of the polymorphs was investigated in a mixture of water and methanol (MeOH) under agitated crystallization. At a low concentration of MeOH (0 and 10 wt%), the α-form is precipitated at the initial stage of crystallization regardless of the seed form. Thereafter the α-form is transformed into the β-form. In 30% MeOH, only the β-form is precipitated regardless of the seed form. In 30% MeOH without agitation, the β-form grew on the surface of the α-seed crystal. The effect of MeOH on the crystal growth rate was also examined at 10℃ and at a prescribed supersaturation ratio. As the MeOH concentration increased, the crystal growth rate of the α-form decreased and that of the β-form inversely increased. These results are discussed with regard to the conformer of taltirelin in solution.
机译：塔特瑞林是一种中枢神经系统活化剂，具有两种晶体形式（α和β形式）。在搅拌下，在水和甲醇（MeOH）的混合物中研究了溶剂对多晶型物结晶行为的影响。在低浓度的MeOH（0和10 wt％）下，无论晶种形式如何，α-型都会在结晶初期沉淀出来。此后，α-形式转化为β-形式。在30％的MeOH中，无论种子形式如何，只有β形式沉淀。在没有搅拌的30％MeOH中，β晶型在α晶种的表面上生长。还考察了MeOH对晶体生长速率的影响（在10℃和规定的过饱和比下）。随着MeOH浓度的增加，α-型的晶体生长速率降低，而β-型的晶体生长速率反之增加。就溶液中他替瑞林的构象异构体讨论了这些结果。

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