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首页> 外文期刊>Journal of Crystal Growth >Studies on the effect of different operational parameters on the crystallization kinetics of α-lactose monohydrate single crystals in aqueous solution
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Studies on the effect of different operational parameters on the crystallization kinetics of α-lactose monohydrate single crystals in aqueous solution

机译：不同操作参数对水溶液中α-乳糖一水合物单晶结晶动力学影响的研究

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摘要

Supersaturation dependent nucleation, size and morphology of alpha-lactose monohydrate (α-LM) crystals from aqueous solution were investigated by adopting two different crystallization methods, slow evaporation and fast evaporation, in the supersaturation range between σ=0.05 and 1.30. The induction period of nucleation is comparatively long in case of slow evaporation and is very short in case of fast evaporation process as the interconversion between α-L and β-L is uncontrollable in the former and is under control in the latter case. Moreover a-LM crystals with tomahawk morphology were obtained throughout the supersaturation range by slow evaporation method whereas crystals with tomahawk, triangular and needle-like morphologies were obtained in supersaturation ranges σ=0.05-0.5, σ=0.5-0.9 and σ=0.9-1.30 respectively by fast evaporation method. Experimentally observed nucleation parameters were verified with theoretically deuced values. It is realized that the fast evaporation method employed in the present study is found to be highly efficient in controlling the interconversion between α-L and β-L as well as in suppressing the inhibitory activity of β molecule on the nucleation and growth of α-LM crystals when compared to conventional slow evaporation method and is successful in producing the industrially preferred needle-like crystals at high supersaturation ranges.
机译：采用两种不同的结晶方法，慢速蒸发和快速蒸发，在σ= 0.05和1.30之间的过饱和度范围内研究了水溶液中α-乳糖一水合物（α-LM）晶体的过饱和依赖性成核，大小和形态。在缓慢蒸发的情况下，成核的诱导期相对较长，而在快速蒸发过程的情况下，成核的诱导期非常短，因为α-L和β-L之间的相互转化在前者中是不可控的，而在后者情况中则处于受控状态。此外，通过慢速蒸发方法在整个过饱和范围内获得了具有战斧形貌的a-LM晶体，而在过饱和范围σ= 0.05-0.5，σ= 0.5-0.9和σ= 0.9-下获得了具有战斧形，三角形和针状形貌的晶体。 1.30分别采用快速蒸发法。实验观察到的成核参数已用理论推导的值进行了验证。已经认识到，发现本研究中使用的快速蒸发方法在控制α-L和β-L之间的相互转化以及抑制β分子对α-L的成核和生长的抑制活性方面非常有效。与传统的慢速蒸发方法相比，LM晶体可以成功地在高过饱和范围内生产出工业上优选的针状晶体。

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