Crystalline coats or hollow crystals as tools for product design in pharmaceutical industry

J. Ulrich; A. Schuster; T. Stelzer

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Crystalline coats or hollow crystals as tools for product design in pharmaceutical industry

机译：结晶涂层或中空晶体作为制药行业产品设计的工具

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The coating of pharmaceutical compounds is a field of high interest. As most of the coating materials form an amorphous layer around the material, the studies on crystalline coatings are rare. In this work the progress in this domain should be summarized and innovative results concerning crystalline hollow needles as coating material are presented. Since the first reports on needles formed via a solvent-mediated phase transition from solvates to hydrates, the field could be widened to hydrate-to-anhydrate and anhydrate-to-hydrate transformations. Novel investigations on hollow theophylline monohydrate and carbamazepine dihydrate needles are presented. It is shown that the inclusion of substances into the hollow needle crystals is feasible by simple means, which enable an application in industry as coating for sensitive materials.

机译：药物化合物的涂层是令人关注的领域。由于大多数涂料在材料周围形成非晶层，因此对晶体涂层的研究很少。在这项工作中，应该总结该领域的进展，并提出有关结晶空心针作为涂层材料的创新成果。由于首次报道了通过溶剂介导的从溶剂合物到水合物的相变而形成的针，因此该领域可以扩大到水合物到无水物和无水物到水合物的转变。提出了对空心茶碱一水合物和卡马西平二水合物针头的新研究。结果表明，通过简单的方法将物质包含在空心针状晶体中是可行的，这使得在工业上能够用作敏感材料的涂层。

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来源
《Journal of Crystal Growth》 |2013年第1期|235-237|共3页
作者
J. Ulrich; A. Schuster; T. Stelzer;
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作者单位

Martin-Luther-Universitaet Halle-Wittenberg, Zentrum fuer Ingenieurwissenschaften, Verfahrenstechnik/TVT, D-06099 Halle, Germany;

Martin-Luther-Universitaet Halle-Wittenberg, Zentrum fuer Ingenieurwissenschaften, Verfahrenstechnik/TVT, D-06099 Halle, Germany;

Martin-Luther-Universitaet Halle-Wittenberg, Zentrum fuer Ingenieurwissenschaften, Verfahrenstechnik/TVT, D-06099 Halle, Germany;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
原文格式 PDF
正文语种 eng
中图分类
关键词
A1. Crystal morphology; A1. Optical microscopy; A1. Phase transition; A2. Growth from solutions; B1. Organic compounds;

机译：A1。晶体形态A1。光学显微镜A1。相变;A2。解决方案的增长;B1。有机化合物;

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Crystalline coats or hollow crystals as tools for product design in pharmaceutical industry

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