Lactose particle engineering: Influence of ultrasound and anti-solvent on crystal habit and particle size

E.Kougoulos; I.Marziano; P.R.Miller

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Lactose particle engineering: Influence of ultrasound and anti-solvent on crystal habit and particle size

机译：乳糖颗粒工程：超声和抗溶剂对晶体习性和粒径的影响

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This study focuses on ultrasound-assisted anti-solvent crystallization of lactose, expanding on previous studies and presenting, for the first time, the results of large scale implementation of sonocrystalliza-tion for lactose. The results further clarify the interplay between solution chemistry - namely the role of (β-lactose - and crystallization, representing a step forward in the fine tuning of lactose properties for pharmaceutical manufacturing applications. Batches manufactured at laboratory and pilot scales were extensively characterised, including an approach for the quantification of P-lactose in a-lactose based on powder X-ray diffraction (PXRD), which is described here.

机译：这项研究的重点是超声辅助乳糖的反溶剂结晶，在以前的研究中不断扩展，并首次提出了大规模实施乳糖超声结晶的结果。结果进一步阐明了溶液化学之间的相互作用，即（β-乳糖的作用）与结晶之间的相互作用，这代表了对用于制药生产的乳糖特性进行微调的一步。一种基于粉末X射线衍射（PXRD）定量α-乳糖中P-乳糖的方法，在此介绍。

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来源
《Journal of Crystal Growth》 |2010年第23期|p.3509-3520|共12页
作者
E.Kougoulos; I.Marziano; P.R.Miller;
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作者单位

Pfizer Pharma Therapeutics, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK;

rnPfizer Pharma Therapeutics, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK;

rnPfizer Pharma Therapeutics, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
原文格式 PDF
正文语种 eng
中图分类
关键词
A1. Characterization; A1. Recrystallization; A2. Growth from solutions; A2. Industrial crystallization;

机译：A1。表征;A1。重结晶;A2。解决方案的增长;A2。工业结晶;

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Lactose particle engineering: Influence of ultrasound and anti-solvent on crystal habit and particle size

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