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Simplex optimization of protein crystallization conditions

机译:蛋白质结晶条件的单纯优化

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Simlex algorithms have been used to optimize for size, number and morphology of lysozyme and apoferritincrystals. This approach requires fewer experiments than the single-factor-at-a-time method or factorial designs and will be usefull in conserving materials on the International Space Station. The simplex method has the possible advantage that it conserves on matrials by reducing the number of experiments required to optimize a crystallization system. The process is iterative and exploratory and should allow optimum microgravity conditions to be determined which might very well be different from the optimum conditions on Earth.
机译:Simlex算法已用于优化溶菌酶和载铁蛋白晶体的大小,数量和形态。这种方法比一次单因素方法或析因设计所需的实验更少,并且在保存国际空间站上的材料时将很有用。单纯形法可能具有的优点是,通过减少优化结晶系统所需的实验次数,可以节省材料。该过程是反复的和探索性的,应允许确定最佳的微重力条件,该条件可能与地球上的最佳条件完全不同。

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