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首页> 外文期刊>Journal of Crystal Growth >Nucleation and growth of crystalline ribbons in diastereomeric ephedrine-cyclic phosphoric acid systems
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Nucleation and growth of crystalline ribbons in diastereomeric ephedrine-cyclic phosphoric acid systems

机译:非对映体麻黄碱-环磷酸体系中晶带的形核和生长

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摘要

In an attempt to understand the fast formation of diastereomerically enriched crystals in a Dutch resolution system, the nucleation and growth behaviour of such a system was investigated by in situ optical microscopy. Nucleation was observed to follow two pathways: nuclei crystal formation and ribbon formation. The shape of these ribbons (flat, helical or twisted) was dependent on the composition of the system. Hindrance during growth of the ribbons was observed to result in cleavage of the ribbons, creating new crystals. After continued growth, the ribbons develop into needles. This is most likely caused by the introduction of defects and not by a change in crystal polymorph.
机译:为了理解在Dutch分辨率系统中非对映体富集晶体的快速形成,通过原位光学显微镜研究了这种系统的成核和生长行为。观察到成核遵循两个途径:核晶体形成和带形成。这些色带的形状(扁平,螺旋形或扭曲形)取决于系统的组成。观察到条带生长期间的阻碍导致条带分裂,产生新的晶体。持续生长后,色带发展成针状。这很可能是由引入缺陷而不是由晶体多晶型物的变化引起的。

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