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首页> 外文期刊>Journal of dairy research >Effects of 2,4-thiazolidinedione (TZD) on milk fatty acid profile and serum vitamins in dairy goats challenged with intramammary infusion of Streptococcus uberis
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Effects of 2,4-thiazolidinedione (TZD) on milk fatty acid profile and serum vitamins in dairy goats challenged with intramammary infusion of Streptococcus uberis

机译：2,4-噻唑烷二酮（TZD）对牛奶犬牛奶脂肪酸型和血清维生素的影响致癖患者静脉内输注肠道

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摘要

The study included two experiments. In the first, 24 lactating Saanen dairy goats received low-energy diet without vitamin supplements. Twelve goats received a daily Ⅳ injection of 2,4-thiazolidinedione (TZD), others received saline injection. A week later, 6 goats from each treatment were challenged with intramammary infusion (IMI) of saline (CTRL) or Streptococcus uberis. In the second experiment, 12 Saanen lactating dairy goats received supplemental vitamins to reach NRC recommendation level. Six goats in each group were injected with TZD or saline daily, and 14 d later received Streptococcus uberis IMI in the right half of the udder. The hypotheses were (1) TZD does not affect the level of retinol in blood, and (2) the fatty acid profile is affected by the interaction between mammary infection and TZD in dairy goats. In the first experiment blood samples were collected on d -7, -2, 1, 2, 12 and milk samples were collected on d -8, 1, 4, 7, and 12, both relative to IMI. In the second experiment, blood samples were collected on d-15, 0, 1, and 10 relative to IMI. Milk and serum samples were analyzed for retinol, a-tocopherol and fatty acid profile. Serum retinol and β-carotene concentrations were higher in the second experiment compared to the first. Serum β-carotene and a-tocopherol were greater in TZD than CTRL and there was a TZD×time interaction in the first experiment. In addition, the TZD×time interaction showed that the milk fatty acid were reduced in C16:0 while C18:3 n3 while total omega 3 fatty acids were increased, as well as with minor effect on preventing a transient increase in α-tocopherol in milk. Overall, the TZD may affect the lipid-soluble vitamins and fatty acid profile, potentially altering immune responses, during mastitis in dairy goats.
机译：该研究包括两个实验。在第一个，24个哺乳期Saanen乳制品山羊收到了没有维生素补充剂的低能量饮食。 12只山羊每天收到2,4-噻唑烷二酮（TZD）注射，其他物质接受盐水洗。一周后，每次治疗的6只山羊患有盐水（Ctrl）或链球菌Uberis的型静脉内输注（IMI）挑战。在第二个实验中，12名Saanen哺乳酸乳制山羊接受了补充维生素来达到NRC推荐水平。每组中的六只山羊每天注射TZD或盐水，14 d以后在乳房的右半部分接受了链球菌Uberis IMI。假设是（1）TZD不会影响血液中的视黄醇水平，（2）脂肪酸谱受乳制山羊乳房感染与TZD之间的相互作用的影响。在第一实验中，在D-1,4,7和12上收集在D-1,2,12,12，12，相对于IMI的D -8,1,4,7和12上收集血液样品。在第二种实验中，相对于IMI在D-15,0,1和10上收集血样。分析牛奶和血清样品用于视黄醇，α-生育酚和脂肪酸谱。与第一实验相比，血清视黄醇和β-胡萝卜素浓度较高。血清β-胡萝卜素和α-生育酚比CTRL更大，并且在第一实验中存在TZD×时间相互作用。此外，TZD×时间相互作用显示乳脂酸在C16：0中减少，而C18：3 N3虽然总ω3脂肪酸增加，但对防止α-生育酚的瞬时增加进行了微小的影响牛奶。总体而言，TZD可能影响脂溶性维生素和脂肪酸型材，潜在地改变免疫应答，在乳房山羊的乳腺炎中。

著录项

  • 来源
    《Journal of dairy research》 |2020年第4期|416-423|共8页
  • 作者

    Chia-Yu Tsai; Fernanda Rosa; Massimo Bionaz; Pedram Rezamand;

  • 作者单位

    Department of Animal and Veterinary Science University of Idaho Moscow ID 83844 USA;

    Department of Animal and Rangeland Sciences Oregon State University Corvallis OR 97331 USA;

    Department of Animal and Rangeland Sciences Oregon State University Corvallis OR 97331 USA;

    Department of Animal and Veterinary Science University of Idaho Moscow ID 83844 USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    2,4-thiazolidinedione; fatty acid profile; goat; mastitis; vitamin;

    机译：2,4-噻唑烷二酮;脂肪酸谱;山羊;乳腺炎;维他命;

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