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Dietary phytanic acid-induced changes in tissue fatty acid profiles in mice

机译：小鼠组织脂肪酸谱的膳食植物酸诱导的变化

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摘要

The aims of this research communication were to investigate the in vivo tissue accumulation of phytanic acid (PA) and any changes in the tissue fatty acid profiles in mice. Previous in vitro studies have demonstrated that PA is a milk component with the potential to cause both beneficial effects on lipid and glucose metabolism and detrimental effects on neuronal cells. However, there is limited information about its in vivo actions. In this study, mice were fed diets containing either 0.00 or 0.05% 3RS, 7R, 11R-PA, which is the isomer found in milk and the human body. After 4 weeks, adipose tissue, liver and brain were harvested and their fatty acid profiles were determined by gas chromatographic analysis. The results showed that PA and its metabolite pristanic acid accumulated in the adipose tissue of PA-fed mice, and that dietary PA decreased the hepatic compositions of several saturated fatty acids such as palmitic acid while increasing the compositions of polyunsaturated fatty acids including linoleic acid and docosahexaenoic acid. However, dietary PA neither accumulated nor had a high impact on the fatty acid profile in the brain. These results suggested that dietary PA could exert its biological activities in adipose tissue and liver, although the brain is relatrwely less affected by dietary PA. These data provide a basis for understanding the in vivo physiological actions of PA.
机译：该研究通信的目的是研究植物酸（PA）的体内组织积累以及小鼠中组织脂肪酸谱的任何变化。以前的体外研究表明，PA是牛奶成分，其潜在可能对脂质和葡萄糖代谢的有益作用和对神经元细胞的不利影响。但是，有关其体内动作的信息有限。在该研究中，小鼠喂养含有0.00或0.05％3RS，7​​R，11R-PA的饮食，其是在牛奶和人体中发现的异构体。在4周后，收获脂肪组织，肝细胞和脑，并通过气相色谱分析测定它们的脂肪酸型材。结果表明，PA和其代谢物常规酸积聚在Pa馈电小鼠的脂肪组织中，膳食PA降低了几种饱和脂肪酸如棕榈酸的肝脏组合物，同时增加了包括亚油酸的多不饱和脂肪酸的组成二十二碳己酸。然而，膳食PA既不积累也不会对大脑中脂肪酸谱产生高影响。这些结果表明，膳食PA可以在脂肪组织和肝脏中发挥其生物学活性，尽管大脑受膳食PA的影响重少。这些数据为了解PA的体内生理行为提供了基础。

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  • 来源
    《Journal of dairy research》 |2020年第4期|498-500|共3页
  • 作者

    Tomonori Nakanishi; Kazuhiro Kagamizono; Sayaka Yokoyama; Ryoji Suzuki; Hiroyuki Sakakibara; Kazuhiro Sugamoto; Laurie Erickson; Satoshi Kawahara;

  • 作者单位

    Department of Biochemistry and Applied Biosciences Faculty of Agriculture University of Miyazaki Miyazaki Japan;

    Department of Biochemistry and Applied Biosciences Faculty of Agriculture University of Miyazaki Miyazaki Japan;

    Department of Biochemistry and Applied Biosciences Faculty of Agriculture University of Miyazaki Miyazaki Japan;

    Department of Biochemistry and Applied Biosciences Faculty of Agriculture University of Miyazaki Miyazaki Japan;

    Department of Biochemistry and Applied Biosciences Faculty of Agriculture University of Miyazaki Miyazaki Japan;

    Department of Applied Chemistry Faculty of Engineering University of Miyazaki Miyazaki Japan;

    Department of Biology Harold Washington City College of Chicago Chicago IL USA Department of Health Sciences Blitstein Institute of Hebrew Theological College Chicago IL USA;

    Department of Biochemistry and Applied Biosciences Faculty of Agriculture University of Miyazaki Miyazaki Japan;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Phytanic acid; Pristanic acid; Tissue fatty acid profile; Mouse;

    机译：植酸酸;常青酸;组织脂肪酸谱;鼠;

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