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首页> 外文期刊>Journal of dairy research >Determination of neonatal serum immunoglobulin G concentrations associated with mortality during the first 4 months of life in dairy heifer calves
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Determination of neonatal serum immunoglobulin G concentrations associated with mortality during the first 4 months of life in dairy heifer calves

机译：奶牛犊出生后头四个月与死亡率相关的新生儿血清免疫球蛋白G浓度的测定

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摘要

Colostral administration practices on dairy farms have significantly improved over the last 15-20 years resulting in prevalence of calves ingesting insufficient colostrum decreasing from 35-40% to 19%. Despite these improvements, the serum immunoglobulin G (IgG) concentration of ≥1000 g/dl and serum total protein (TP) concentrations of ≥5.2 g/dl are considered indicative of adequate transfer of immunity. We hypothesised that the current serum IgG concentrations of ≥1000 mg/dl is too low to indicate adequate transfer of colostral immunity on modern dairies. The objective of this study was to determine the serum IgG and TP concentrations indicating adequate transfer of passive immunity in dairy heifer calves. A cohort study of 1290 heifers from a calf raising facility for 48 dairy farms was performed. Heifers were assigned into strata based on serum IgG and TP concentrations. Mortality events were recorded for the heifers for 4 months. Interval likelihood ratios for mortality were calculated for heifers in each stratum of serum IgG or TP concentrations. Logistic regression to predict probability of mortality events was performed. Estimates of probability of survival were evaluated using survival analysis. Serum strata of ＜1500, 1501-2000 or ＞2500 were not significant predictors of mortality during the 120d of rearing. Serum IgG concentration was not a significant predictor of hazard for mortality. In contrast to previous studies, serum IgG and TP concentrations of 2001-2500 mg/dl and 5.8-6.3 g/dl respectively, were considered optimum for indicating adequate passive transfer of colostral immunity in dairy calves based on the likelihood ratios. On dairies with optimum colostral feeding practices, serum IgG and TP concentrations of 2001-2500 mg/dl and 5.8-6.3 g/dl are recommended as endpoints to indicate adequate passive immunity in dairy calves.
机译：在过去的15-20年中，奶牛场的总行政管理实践得到了显着改善，导致犊牛摄入不足的初乳的患病率从35-40％降至19％。尽管有这些改进，仍认为血清免疫球蛋白G（IgG）浓度≥1000g / dl和血清总蛋白（TP）浓度≥5.2g / dl表示免疫力已充分转移。我们假设当前的血清IgG浓度≥1000mg / dl太低，不足以表明现代乳品厂已经充分转移了初乳免疫力。这项研究的目的是确定表明乳牛小牛的被动免疫充分转移的血清IgG和TP浓度。对来自48个奶牛场的犊牛饲养设施的1290头小母牛进行了队列研究。根据血清IgG和TP浓度将小母牛分为几层。记录了四个小母牛的死亡率事件。计算血清IgG或TP浓度各层中小母牛的死亡率的似然比。进行逻辑回归以预测死亡事件的可能性。使用生存分析评估生存概率的估计。血清＜1500、1501-2000或＞ 2500并不是饲养120d期间死亡率的重要预测指标。血清IgG浓度不是死亡危险的重要预测指标。与以前的研究相反，根据似然比，分别认为2001-2500 mg / dl和5.8-6.3 g / dl的血清IgG和TP浓度最适合指示乳牛犊体内足够的被动免疫转移。在采用最佳初乳喂养方式的奶牛场，建议血清IgG和TP浓度分别为2001-2500 mg / dl和5.8-6.3 g / dl作为终点，以表明奶牛有足够的被动免疫力。

著录项

  • 来源
    《Journal of dairy research》 |2015年第4期|400-406|共7页
  • 作者

    Munashe Chigerwe; Jill V Hagey; Sharif S Aly;

  • 作者单位

    Departments of Medicine and Epidemiology, University of California-Davis, One Shields Avenue, Davis, CA 95616, USA;

    Departments of Medicine and Epidemiology, University of California-Davis, One Shields Avenue, Davis, CA 95616, USA;

    Department of Population Health and Reproduction, University of California-Davis, Veterinary Medicine Teaching and Research Center, 18830 Road 112, Tulare, CA 93274, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Mortality; serum; likelihood ratio; colostrum;

    机译：死亡;血清;似然比;初乳;

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