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首页> 外文期刊>Journal of dairy science >Oxidative stress and acid–base balance during the transition period of neonatal Holstein calves submitted to different calving times and obstetric assistance
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Oxidative stress and acid–base balance during the transition period of neonatal Holstein calves submitted to different calving times and obstetric assistance

机译：新生儿Holstein小牛的过渡期氧化应激和酸碱平衡，提交给不同的钙米次数和产科援助

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摘要

During the neonatal period, constant adaptationsto the extrauterine environment are required. Theseadaptations are made impossible or hindered whenunexpected obstetrical events take place. This studyaimed to identify clinical changes of vitality, metabolicand acid–base balance, and oxidative stress of newborncalves born to assisted dams that experienced differentdurations of calving. A prospective and observationalstudy was conducted with 44 Holstein calves allocatedto 3 groups according to the duration of calving: 2 h (n= 16), 2–4 h (n = 16), and >4 h (n = 12), and to 2 subgroups:spontaneous calving (n = 22) and assisted calving(n = 22). We observed that obstetric assistance wasbeneficial when calving lasted more than 4 h, because100% of assisted calves had a high Apgar score (≥7)at 5 min, similar to that of spontaneously born calvesafter 2 h of calving. Rectal temperature of all calvesremained within normal values, albeit with a reductionat 20 min of life. Calves born after a calving time>4 h had the highest rectal temperatures, especiallythose that required obstetrical assistance. There wasa progressive increase in blood oxygenation with time,but calves in the >4 h group showed the highest partialpressure of carbon dioxide at birth, whereas calves inthe 2 h and 2–4 h groups had lower values. A decreasein partial pressure of CO_2 was observed at 120 min inthe 2–4 h and >4 h groups. In the 2–4 h group, calveswith obstetrical assistance had higher oxidative stress(measured as thiobarbituric acid reactive substances,TBARS) at 120 min of life compared with that at birth.In spontaneously born calves, TBARS increased onlyafter 240 min. In the >4 h group, TBARS increasedprogressively with time, regardless of obstetrical subgroup.Calves born spontaneously within the 2 h grouphad higher TBARS values at birth than calves in the>4 h group with obstetrical assistance. Calves in the>4 h group showed higher levels of glutathione peroxidase(an antioxidant enzyme) at birth than thosein the remaining groups. Glutathione peroxidase decreasedat 120 min in the >4 h group and at 240 minfor the 2 h and 2–4 h groups. In conclusion, obstetricassistance did not improve neonatal vitality and bloodoxygenation when calving lasted less than 2 h. Calvesborn after 2 h of calving showed decreased vitality, hypercapnia,hypoxemia, and increased antioxidant status(glutathione peroxidase).
机译：在新生儿期间，持续适应需要占地环境。这些适应是不可能或妨碍的发生意外的产科活动。这项研究旨在确定活力，代谢的临床变化和酸碱平衡，新生儿的氧化应激犊牛出生于辅助经历不同的水坝产犊的持续时间。潜在观察研究是用44只荷斯坦小牛分配的研究根据产犊持续时间为3组：2小时（n= 16），2-4小时（n = 16），> 4小时（n = 12），以及2个子组：自发的犊牛（n = 22）和辅助产犊（n = 22）。我们观察到产科援助是当产犊持续超过4小时时有益，因为100％的辅助犊牛的APGAR评分（≥7）在5分钟，类似于自发出生的小牛2小时后。所有犊牛的直肠温度仍然在正常值内，尽管减少在20分钟的生活中。犊牛在产犊时间后出生> 4小时有最高的直肠温度，特别是那些需要产科援助的人。有随着时间的推移，血氧的逐步增加，但是在> 4小时的小腿上显示了最高的部分二氧化碳在出生时压力，而小牛2小时和2-4小时组具有较低的值。减少在120分钟内观察到CO_2的分压2-4小时和> 4小时组。在2-4小时，小牛伴有产科援助具有更高的氧化应激（作为硫酰比酸反应性物质测量，与出生时相比，TBARS）在120分钟的生活中。在自发出生的小牛中，TBAR仅增加240分钟后。在> 4小时，TBARS增加随着时间的推移，无论产科亚组如何。在2小时内自发的小牛出生时比小牛在出生时具有更高的TBARS值> 4小时群体，具有产科援助。小牛在> 4小时集团显示出更高水平的谷胱甘肽过氧化物酶（抗氧化剂酶）比那些人在出生时在剩下的群体中。谷胱甘肽过氧化物酶降低在> 4小时群中120分钟，240分钟对于2小时和2-4小时。总之，产科援助并没有改善新生儿生命力和血液当钙持续低于2小时时氧合。小牛产犊2小时后出生表现出降低活力，高曲线，低氧血症，增加抗氧化状态（谷胱甘肽过氧化物酶）。

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  • 来源
    《Journal of dairy science》 |2019年第2期|1542-1550|共9页
  • 作者

    Camila I. Vannucchi; Liege G. Silva; Cristina F. Lucio; Gisele A. L. Veiga;

  • 作者单位

    Department of Animal Reproduction School of Veterinary Medicine and Animal Science University of São Paulo São Paulo SP Brazil 05508-270;

    Department of Animal Reproduction School of Veterinary Medicine and Animal Science University of São Paulo São Paulo SP Brazil 05508-270;

    Department of Animal Reproduction School of Veterinary Medicine and Animal Science University of São Paulo São Paulo SP Brazil 05508-270;

    Department of Animal Reproduction School of Veterinary Medicine and Animal Science University of São Paulo São Paulo SP Brazil 05508-270;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    antioxidant; prolonged calving; acid–base imbalance; Apgar score;

    机译：抗氧化剂;长时间的犊牛;酸碱不平衡;Apgar得分;

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