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首页> 外文期刊>Journal of Developmental and Physical Disabilities >“N of 1” Trials of Methylphenidate in Two Children with Williams Syndrome and Attention Deficit Hyperactivity Disorder
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“N of 1” Trials of Methylphenidate in Two Children with Williams Syndrome and Attention Deficit Hyperactivity Disorder

机译：两名患威廉姆斯综合征和注意缺陷多动障碍儿童的哌醋甲酯“ N of 1”试验

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摘要

Poor attention and motor restlessness are common in Williams syndrome (WS) children, and attention deficit hyperactivity disorder (ADHD) is at least as prevalent in WS as in other mentally handicapped groups. We determined the effectiveness of methylphenidate in two children with WS and ADHD. Each child underwent a double-blind dose-determining assessment to select the optimum dose for “N of 1” trials, which consisted of single subject, placebo-controlled randomized controlled trials with multiple crossovers. A regimen of 5 mg in the morning and 2.5 mg at noon was determined by consensus for both trials. Response to MPH was assessed using parent and teacher Conners ratings, and analyzed separately for each child, using mixed model ANOVA. No significant differences in behavioral ratings between medication and placebo weeks were found during the “N of 1 trials.” We conclude that methylphenidate was not superior to placebo in decreasing ADHD symptoms in these two children with Williams syndrome.
机译：威廉姆斯综合征（WS）儿童常见注意力不足和运动不安，而注意力缺陷多动障碍（ADHD）至少与其他弱智人群中一样普遍。我们确定了哌醋甲酯对两名患有WS和ADHD的儿童的有效性。每个孩子都要接受双盲剂量确定评估，以选择“ N of 1”试验的最佳剂量，该试验由单受试者，安慰剂对照，随机对照试验组成。通过两项试验的共识确定了早晨5 mg和中午2.5 mg的治疗方案。使用父母和老师的Conners评分评估对MPH的反应，并使用混合模型ANOVA对每个孩子分别进行分析。在“ N项1项试验”中，药物治疗和安慰剂周之间的行为评级没有明显差异。我们得出结论，在这两个威廉姆斯综合征儿童中，哌醋甲酯在减轻多动症症状方面不优于安慰剂。

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