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Reliable Classification of Case-Control Studies of Autistic Disorder and Obstetric Complications

机译:自闭症和产科并发症病例对照研究的可靠分类

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摘要

Several reports have suggested an association between obstetric complications and autistic disorder. Since conclusions may be drawn from case-control studies, a methodology to identify case-control studies of autistic disorder and obstetric complications for qualitative and quantitative reviews is needed. We sought to establish the feasibility of blinding of reports as a means to remove biases in meta-analyses of case-control studies of autism and obstetric complications. Therefore, we located published reports of case-control studies of autistic disorder and obstetric complications by a literature search and additional articles. The methods or other appropriate portions of the articles were blindly reviewed for the presence or absence of obstetric complications in cases with autistic disorder matched with at least one control without autistic disorder. Good inter-rater reliability was obtained for case-control studies of autistic disorder (74.6% agreement and κ=.451) and for obstetric complications (84.0% agreement and κ=.658).
机译:几份报告表明,产科并发症和自闭症之间存在关联。由于可以从病例对照研究中得出结论,因此需要一种方法来鉴定自闭症和产科并发症的病例对照研究,以进行定性和定量审查。我们试图建立盲目的报告的可行性,以消除自闭症和产科并发症病例对照研究的荟萃分析中的偏见。因此,我们通过文献检索和其他文章找到了自闭症和产科并发症病例对照研究的已发表报告。在自闭症患者与至少一个无自闭症患者的对照相匹配的情况下,盲目检查了文章的方法或其他适当部分是否存在产科并发症。自闭症病例对照研究(74.6%一致性,κ= .451)和产科并发症(84.0%一致性,κ= .658),获得了良好的评价者间信度。

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