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首页> 外文期刊>Journal of Digital Imaging >Design of a Web-Tool for Diagnostic Clinical Trials Handling Medical Imaging Research
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Design of a Web-Tool for Diagnostic Clinical Trials Handling Medical Imaging Research

机译：用于处理医学影像研究的诊断性临床试验网络工具的设计

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New clinical studies in medicine are based on patients and controls using different imaging diagnostic modalities. Medical information systems are not designed for clinical trials employing clinical imaging. Although commercial software and communication systems focus on storage of image data, they are not suitable for storage and mining of new types of quantitative data. We sought to design a Web-tool to support diagnostic clinical trials involving different experts and hospitals or research centres. The image analysis of this project is based on skeletal X-ray imaging. It involves a computerised image method using quantitative analysis of regions of interest in healthy bone and skeletal metastases. The database is implemented with ASP.NET 3.5 and C# technologies for our Web-based application. For data storage, we chose MySQL v.5.0, one of the most popular open source databases. User logins were necessary, and access to patient data was logged for auditing. For security, all data transmissions were carried over encrypted connections. This Web-tool is available to users scattered at different locations; it allows an efficient organisation and storage of data (case report form) and images and allows each user to know precisely what his task is. The advantages of our Web-tool are as follows: (1) sustainability is guaranteed; (2) network locations for collection of data are secured; (3) all clinical information is stored together with the original images and the results derived from processed images and statistical analysis that enable us to perform retrospective studies; (4) changes are easily incorporated because of the modular architecture; and (5) assessment of trial data collected at different sites is centralised to reduce statistical variance.
机译：新的医学临床研究基于使用不同影像学诊断方式的患者和对照。医学信息系统不适用于采用临床成像的临床试验。尽管商业软件和通信系统专注于图像数据的存储，但它们不适合存储和挖掘新型的定量数据。我们试图设计一种网络工具来支持涉及不同专家，医院或研究中心的诊断性临床试验。该项目的图像分析基于骨骼X射线成像。它涉及一种计算机图像方法，该方法使用了对健康的骨骼和骨骼转移灶中感兴趣区域的定量分析。该数据库使用ASP.NET 3.5和C＃技术针对基于Web的应用程序实现。对于数据存储，我们选择了MySQL v.5.0，这是最受欢迎的开源数据库之一。用户登录是必需的，并且记录了对患者数据的访问以进行审核。为了安全起见，所有数据传输均通过加密连接进行。分散在不同位置的用户可以使用该Web工具。它可以有效地组织和存储数据（案例报告表）和图像，并允许每个用户准确地知道他的任务是什么。我们的Web工具的优点如下：（1）可持续性得到保证； （2）确保收集数据的网络位置； （3）所有临床信息均与原始图像以及从处理过的图像和统计分析中得出的结果一起存储，从而使我们能够进行回顾性研究； （4）由于采用模块化架构，因此更改易于合并； （5）集中评估在不同地点收集的试验数据，以减少统计差异。

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