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Topics in Mathematical Pharmacology

机译:数学药理学主题

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摘要

Mathematical analysis of pharmacological models is becoming increasingly relevant for drug development. Emphasis on mechanistic models has grown and qualitative understanding of complex biological systems has improved a great deal. In this paper we present two examples of basic modular processes which are involved in a wide range of physiological systems. The first model concerns the interaction of a drug with its target, the way the compounds bind and then elicit an effect. The second model is central in signal transduction across the cell wall. Both models demonstrate the complex and interesting dynamics which is directly relevant for the impact of the drug.
机译:药理模型的数学分析与药物开发越来越相关。对机械模型的重视已经增强,对复杂生物系统的定性理解有了很大提高。在本文中,我们介绍了涉及广泛生理系统的基本模块化过程的两个示例。第一个模型涉及药物与其靶标的相互作用,即化合物结合然后引发作用的方式。第二种模型是跨细胞壁信号转导的核心。两种模型均显示出与药物作用直接相关的复杂有趣的动力学过程。

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