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Development and Validation of a Photoplethysmography System for Noninvasive Monitoring of Hemoglobin Concentration

机译：血红蛋白浓度非侵入性监测的光学大量监测系统的开发与验证

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摘要

Background. Traditional invasive hemoglobin (Hb) detection led to delayed diagnosis, operational inefficiency, incorrect critical decision making, and uncomfortable patient experience. To facilitate real-time total hemoglobin (tHb) monitoring, a portable prototype of a noninvasive Hb detection system was developed, and the accuracy of Hb predicted based on partial least squares (PLS) as well as backpropagation artificial neural network (BP-ANN) models was validated. Results. The prototype was combined with a signal processing circuit and a spectrophotometric probe containing 8 wavelength LEDs light source and photodiode array. Laboratory invasive Hb (Lab_tHb) and spot check Hb measurements with PLS (SpHb_PLS) and BP (SpHb_BP) methods were obtained simultaneously by hematology analyzer and the designed system. The invasive and noninvasive estimates of the Hb levels were analyzed using Spearman correlation as well as Bland-Altman plot and receiver operating characteristic (ROC) curve analysis. A total of 238 volunteers had attempted laboratory invasive and noninvasive spot check Hb measurements. Mean Lab_tHb, SpHb_PLS, and SpHb_BP were 13.6 +/- 1.80 g/dL, 13.5 +/- 1.07 g/dL, and 13.6 +/- 1.06 g/dL, respectively. Noninvasive SpHb_PLS (r = 0.61, p0.001) and SpHb_BP (r = 0.62, p0.001) had a strong correlation with invasive tHb values. The Bland-Altman plot showed excellent consistency between the proposed noninvasive methods and laboratory invasive reference. In ROC analysis, PLS and BP models were good at predicting Hb = 12 g/dL with area under the curve of 0.828 and 0.824, respectively. Observed differences between invasive and noninvasive Hb measurements displayed no significant correlation with perfusion index values. Conclusions. The result confirmed that noninvasive Hb monitoring had an excellent correlation with traditional invasive Hb measurement. Furthermore, it is suggested that the developed prototype has the potential for the noninvasive detection of Hb concentration with the methods of PLS and BP-ANN.
机译：背景。传统的血液血红蛋白（HB）检测导致延迟诊断，运营低效率，不正确的严重决策以及不舒服的患者体验。为了便于实时总血红蛋白（THB）监测，开发了一种非侵入性HB检测系统的便携式原型，基于部分最小二乘（PLS）以及背部化人工神经网络（BP-ANN）预测的HB的准确性模型被验证。结果。原型与信号处理电路和含有8个波长LED光源和光电二极管阵列的分光光度探针组合。通过血液分析仪和设计的系统同时获得实验室侵入性HB（Lab_thb）和点检查HB测量，并通过PLS（SPHB_PL）和BP（SPHB_BP）方法获得。使用Spearman相关性以及Bland-Altman绘图和接收器操作特性（ROC）曲线分析来分析HB水平的侵入性和非侵入性估计。共有238名志愿者尝试了实验室侵入性和非侵入性点检查HB测量。平均Lab_thb，sphb_pls和sphb_bp分别为13.6 +/- 1.80g / dl，13.5 +/- 1.07 g / dl，以及13.6 +/- 1.06 g / dl。非侵入性SPHB_PLS（r = 0.61，p <0.001）和SPHB_BP（r = 0.62，p <0.001）与侵入性THB值具有很强的相关性。 Bland-Altman Plot在提议的非侵入性方法和实验室侵入性参考之间表现出优异的一致性。在ROC分析中，PLS和BP模型擅长预测HB＆ = 12g / dL，分别在0.828和0.824的曲线下的面积。观察到侵入性和非侵入性HB测量之间的差异显示与灌注指标值无显着相关性。结论。结果证实，非侵入性HB监测与传统的侵入性HB测量具有出色的相关性。此外，建议开发的原型具有与PLS和BP-ANN的方法的非侵入性检测HB浓度的可能性。

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  • 来源
    《Journal of electrical and computer engineering》 |2020年第1期|3034260.1-3034260.9|共9页
  • 作者

    Liu Hongyun; Peng Fulai; Hu Minlu; Shi Jinlong; Wang Guojing; Ai Haiming; Wang Weidong;

  • 作者单位

    Chinese Peoples Liberat Army Gen Hosp Dept Biomed Engn Beijing 100853 Peoples R China|Chinese Peoples Liberat Army Gen Hosp Ctr Med Device R&D Clin Evaluat Beijing 100853 Peoples R China;

    Chinese Acad Sci Shandong Inst Adv Technol Beijing 250000 Peoples R China;

    Chinese Peoples Liberat Army Gen Hosp Ctr Med Device R&D Clin Evaluat Beijing 100853 Peoples R China;

    Chinese Peoples Liberat Army Gen Hosp Dept Biomed Engn Beijing 100853 Peoples R China|Chinese Peoples Liberat Army Gen Hosp Ctr Med Device R&D Clin Evaluat Beijing 100853 Peoples R China;

    Chinese Peoples Liberat Army Gen Hosp Dept Biomed Engn Beijing 100853 Peoples R China|Chinese Peoples Liberat Army Gen Hosp Ctr Med Device R&D Clin Evaluat Beijing 100853 Peoples R China;

    Beijing Open Univ Dept Comp Sci Beijing 100081 Peoples R China;

    Chinese Peoples Liberat Army Gen Hosp Dept Biomed Engn Beijing 100853 Peoples R China|Chinese Peoples Liberat Army Gen Hosp Ctr Med Device R&D Clin Evaluat Beijing 100853 Peoples R China;

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