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首页> 外文期刊>Pediatric Research >Postnatal Changes in Oxygen Transport of Term, Premature, and Sick Infants: The Role of Red Cell 2,3-Diphosphoglycerate and Adult Hemoglobin
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Postnatal Changes in Oxygen Transport of Term, Premature, and Sick Infants: The Role of Red Cell 2,3-Diphosphoglycerate and Adult Hemoglobin

机译：术语，早产和生病婴儿的出生后变化：红细胞2,3-二磷酸盐和成人血红蛋白的作用

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Extract: In view of previous studies which did not show a precise relation between the percentage fetal hemoglobin and the position of the oxygen hemoglobin equilibrium curve, this problem was reexamined taking into account both the concentration of fetal hemoglobin and the 2,3-diphosphoglycerate (2,3-DPG) content of the cell.Forty-eight normal infants weighing 2500 g or more at birth were studied on days 1 and 5 of life and then at 3 and 6–9 weeks, and at 3–4, 5–6, and 8–11 months of age. Fifty-six ingfants ranging in birth weight from 900 to 2420 g were studied during the first 8 days of life and then at 2? to 3-week intervals until approximately 16 weeks of life. Twelve premature infants who were ill with the respiratory distress syndrome were also studied.Laboratory procedures consisted of measurement of total hemoglobin, fetal hemoglobin, red cell 2,3-DPG, and oxygen equilibrium curves.The “functioning DPG fraction” in millimicromoles per milliliter red blood cells (RBC) was obtained by multiplication of the total red cell DPG content (millimicromoles per milliliter RBC) by the percentage of adult hemoglobin.These studies confirm previous observations that the term infant begins life with blood that has an increased affinity for oxygen. During the first few months of life the oxygen-hemoglobin equilibrium curve gradually shifts to the right and between 4 and 6 months of age becomes similar to that observed in the normal adult.The change in P60 in these infants correlated neither with the change in red cell DPG content alone nor with the decline in fetal hemoglobin alone. Instead, the progressive decrease in oxygen affinity during the first 6 months of life correlated significantly (r = 0.876, P 50 s that are lower than those of healthy infants of similar gestational age and birth weight. This appears to be primarily a result of a decrease in red cell DPG concentration. It is this type of infant who may benefit from exchange transfusion with fresh adult blood.
机译：提取物：鉴于以前没有显示胎儿血红蛋白的百分比与氧血红蛋白平衡曲线的位置之间的精确关系的研究，考虑到胎儿血红蛋白和2,3-二磷酰基（以下）的浓度重新审视该问题2,3-dpg）细胞的含量。在生命的第1天和第5天，在出生时进行2500克或以上的正常婴儿，然后在3和6-9周，3-4,5-4 6和8-11个月。在生命的前8天内，研究了900至2420克出生体重的五十六个英制的含量，然后在2时进行到3周的间隔直到大约16周的生命。还研究了十二次早产儿，患有呼吸窘迫综合征的病例。制造理程序包括总血红蛋白，胎儿血红蛋白，红细胞2,3-DPG和氧平衡曲线的测量。毫米摩尔中的“功能性DPG级分”为每毫升通过通过成年血红蛋白的百分比乘以总红细胞DPG含量（毫米摩尔/毫升RBC）来获得红细胞（RBC）。这些研究证实了先前的观察结果，术语婴儿开始与血液具有增加的亲和力的血液。在生命的前几个月，氧气 - 血红蛋白平衡曲线逐渐转移到右侧，4至6个月之间的年龄与正常成人中观察到的右侧。这些婴儿在这些婴儿的变化既不随着红色的变化相关单独的细胞DPG含量单独也不是胎儿血红蛋白的下降。相反，在寿命的前6个月期间氧亲和力的逐渐降低显着相关（r = 0.876，p 50s低于类似孕期年龄和出生体重的健康婴儿的p 50s。这似乎主要是a的结果减少红细胞DPG浓度。这是这种类型的婴儿，他们可能会受益于新鲜成年血液的交换输血。

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