...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Antibody-mediated and delayed-type hypersensitivity reactions to Brucella skin test antigens in guinea pigs.
【24h】

Antibody-mediated and delayed-type hypersensitivity reactions to Brucella skin test antigens in guinea pigs.

机译：抗体介导和延迟型超敏反应反应豚鼠的Brucella皮肤测试抗原。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Cutaneous hypersensitivity responses to brucella antigens of different composition were studied in guinea pigs sensitized by infection with smooth brucella or immunization with killed rough brucella in adjuvant. These animals had circulating antibodies to smooth lipopolysaccharide or protein antigens, respectively. Intradermal skin tests, active cutaneous anaphylaxis, passive cutaneous anaphylaxis, and immunodiffusion tests were performed. Delayed-type hypersensitivity reactions uncomplicated by accompanying antibody-mediated reactions were seen only in infected guinea pigs with protein antigen that was entirely free of lipopolysaccharide. In the adjuvant-immunized animals, the protein antigen evoked overlapping antibody-mediated and delayed-type reactions. Lipopolysaccharide and polysaccharide preparations contained varying amounts of protein components. In infected animals, reactions of these antigens were clearly antibody mediated, but participation of delayed-type hypersensitivity could not be excluded. In adjuvant-immunized animals, the antibody-mediated reaction to the lipopolysaccharide preparation was caused by its protein component.
机译：通过用光滑的布鲁氏感染或用杀死的粗糙布鲁氏在佐剂中致敏于不同组合物对不同组合物的Brucella抗原对不同组合物的抗原的反应。这些动物分别对平滑的脂多糖或蛋白质抗原分别具有循环抗体。进行皮肤皮肤测试，有效皮肤过敏性，被动皮肤过敏性和免疫分离性试验。通过伴随抗体介导的反应简单的延迟型过敏反应仅在感染的豚鼠中观察到具有完全没有脂多糖的蛋白质抗原的蛋白质抗原。在佐剂 - 免疫动物中，蛋白质抗原诱发重叠的抗体介导和延迟型反应。脂多糖和多糖制剂含有不同量的蛋白质组分。在感染的动物中，这些抗原的反应明显介导抗体，但不能排除延迟型超敏反应的参与。在佐剂免疫动物中，对脂多糖制剂的抗体介导的反应是由其蛋白质组分引起的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号