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首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >Relationship of Serum Bilirubin Levels to Ototoxicity and Deafness in High-Risk Low-Birth-Weight Infants
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Relationship of Serum Bilirubin Levels to Ototoxicity and Deafness in High-Risk Low-Birth-Weight Infants

机译：高危低生猪婴幼儿血清胆红素水平与卵毒性和耳聋的关系

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During a 4-year period, 12 premature infants, all less than 34 weeks of gestation and all with a bilirubin level above 240 μmol/L (14 mg/dL) were determined to have bilateral sensorineural deafness. In order to investigate how far the hyperbilirubinemia or any associated factor might have been a causative factor, all infants of 34 weeks of gestation or less who had a serum bilirubin level above 240 μmol/L were investigated. For a period of 4 years, 99 infants meeting these criteria were classified as high risk or low risk on the basis of perinatal risk factors. Eight of the 22 high-risk infants with birth weight less than 1,500 g, but only two of 43 high-risk infants with birth weight greater than 1,500 g were deaf ( P .05). The deaf infants were also matched with infants of normal hearing who had similar bilirubin levels and the same number of adverse perinatal factors. The mean duration of hyperbilirubinemia was significantly longer in the deaf infants ( P .02), and they appeared to have a greater number of acidotic episodes while they were hyperbilirubinemic. These findings suggest that in healthy preterm infants with birth weight greater than 1,500 g, high bilirubin levels carry little risk, whereas a serum bilirubin level greater than 240 μmol/L in highrisk preterm infants with birth weight of 1,500 g or less is associated with a high risk of deafness.
机译：在4年期间，12个早产儿，妊娠少34周，并确定胆红素水平以上240μmol/ L（14mg / dl）的胆红素水平均有双侧感觉耳聋。为了研究高胆管血症或任何相关因素可能是一种致病因素的距离，研究了妊娠34周或较少的所有婴儿的妊娠或较少的血清胆红素水平以上240μmol/ L.为期4年，将这些标准的99名婴儿在围产期危险因素的基础上被归类为高风险或低风险。出生体重的22名高风险婴儿中的八个小于1,500克，但只有43名高风险婴儿出生体重大于1,500克的婴儿（P <.05）。聋婴儿也与婴儿的正常听证患者匹配，婴儿患有类似的胆红素水平和相同数量的不良围产物因素。聋婴儿的血红蛋白血症的平均持续时间明显更长（P <.02），它们似乎具有更多的酸性发作，同时它们是高胆管血症的同时。这些研究结果表明，在出生体重大于1,500克的健康早产儿，高胆红素水平携带少量风险，而血清胆红素水平大于240μmol/ L的高次级早产儿，出生体重为1,500g或更小的婴儿。与a相关高耳聋风险。

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