首页> 外文期刊>Infection and immunity >Persistent enhancement of cell-mediated and antibody immune responses after administration of muramyl dipeptide derivatives with antigen in metabolizable oil.
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Persistent enhancement of cell-mediated and antibody immune responses after administration of muramyl dipeptide derivatives with antigen in metabolizable oil.

机译:在代谢油中施用抗原施用蛋白二肽衍生物后细胞介导和抗体免疫应答的持续增强。

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摘要

Circulating antibody titers can be increased when the antigen is administered in an aqueous medium with N-acetylmuramyl-L-alanyl-D-isoglutamine (muramyl dipeptide). Results reported here show that cell-mediated immunity can be demonstrated when this synthetic adjuvant or an active analog is injected with an antigen (ovalbumin) in metabolizable squalane emulsion. Under these conditions a lipophilic derivative of muramyl dipeptide was shown to be even more active and to enhance long-lasting immune responses.
机译:当抗原在用N-乙酰胺基-L- alanyl-丁胺(Muramyl二肽)中施用抗原时,可以增加循环抗体滴度。结果报告的结果表明,当将该合成佐剂或活性的模拟注入抗原(卵酸)中以代谢的鳞片乳液注射时,可以对细胞介导的免疫。在这些条件下,蛋白基二肽的亲脂性衍生物被证明甚至更活跃并增强长期的免疫应答。

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