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首页> 外文期刊>Infection and immunity >Biological activity of Bordetella pertussis in lipopolysaccharide-resistant mice.
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Biological activity of Bordetella pertussis in lipopolysaccharide-resistant mice.

机译：脂多糖抗性小鼠Bordetella Pertussis的生物活性。

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摘要

Effects of Bordetella pertussis organisms, such as adjuvanticity, induction of hypersplenia, and leukocytosis as well as modification of nonspecific resistance to infection and typical morphological response of lymphatic organs, were studied in the lipopolysaccharide-resistant C3H/HeJ mouse strain. It was shown that B. pertussis exerted all of these effects in C3H/HeJ mice, although the morphological response, hypersplenia, and modification of resistance to infection with Listeria monocytogenes in such animals were less pronounced than those in lipopolysaccharide-sensitive mouse strains. This indicated that the biological activity of B. pertussis as determined in the present studies, is due partly to structural components other than lipopolysaccharide.
机译：Bordetella Pertussis生物的影响，如佐剂，诱导患者，白细胞增多，以及淋巴结器的无特异性耐感染和典型形态响应的修饰，均在脂多糖抗性C3H / HEJ小鼠菌株中进行研究。结果表明，B.Pertussis在C3H / HEJ小鼠中施加了所有这些作用，尽管在这些动物中具有李斯特菌单核细胞增生的潜能凋亡的形态反应，患有患者和改性的形态反应，但比脂多糖敏感小鼠菌株的抗性更显着。这表明，如本研究中确定的B.Pertussis的生物活性部分是由于脂多糖之外的结构组分。

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