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首页> 外文期刊>Infection and immunity >Reactivity and immunogenicity of bivalent (AC) and tetravalent (ACW135Y) meningococcal vaccines containing O-acetyl-negative or O-acetyl-positive group C polysaccharide.
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Reactivity and immunogenicity of bivalent (AC) and tetravalent (ACW135Y) meningococcal vaccines containing O-acetyl-negative or O-acetyl-positive group C polysaccharide.

机译：二价（AC）和四价（ACW135Y）脑膜炎球菌疫苗的反应性和免疫原性含有O-乙酰基阴性或O-乙酰基阳性C多糖。

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The immunogenicity and the reactivity of two bivalent (AC) and two tetravalent (ACW135Y) meningococcal vaccines containing either the O-acetyl-positive or the O-acetyl-negative group C polysaccharide were compared in healthy adolescent and adult volunteers. The vaccines contained high-molecular-weight, purified capsular meningococcal polysaccharides and were administered subcutaneously at a dose of 50 micrograms for each polysaccharide. Reactivity was low for all vaccines, and the tetravalent vaccines were not significantly more reactive than the bivalent vaccines. Immunogenicity was measured by assay of bactericidal antibodies in pre- and postvaccination sera. More than 90% of the vaccines had at least a fourfold increase in the bactericidal antibody titer against each group of meningococcus represented in the vaccines. Addition of polysaccharide W135 and polysaccharide Y to polysaccharides A and C did not alter the immunogenicity of the latter polysaccharides. Thus, there is no evidence of antigenic competition with the tetravalent vaccine. Comparison of the antibody response to the O-acetyl-positive and the O-acetyl-negative variants of group C polysaccharide in the bivalent vaccines, as measured by both bactericidal and enzyme-linked immunosorbent assays, indicates that in adults, the two types of group C polysaccharide are similarly immunogenic.
机译：在健康的青少年和成人志愿者将含有O-乙酰基阳性或O-乙酰基阴性C多糖的两双偶（AC）和两个四价（ACW135Y）脑膜炎疫苗的免疫原性和反应性。疫苗含有高分子量纯化的荚膜脑膜炎球菌多糖，并在每种多糖的剂量为50微克的剂量下皮下施用。所有疫苗的反应性低，并且四价疫苗比二价疫苗明显更具反应性。通过测定免疫原性测定通过在后和后血清中的杀菌抗体测定。在疫苗中代表的每组脑膜炎球菌中，抗体抗体滴度中的超过90％的疫苗至少增加了四倍。添加多糖W135和多糖Y对多糖A和C未改变后者多糖的免疫原性。因此，没有抗原疫苗的抗原竞争的证据。通过杀菌和酶联免疫吸附测定测量的二价疫苗中C组多糖的邻乙酰基阳性和乙酰阳性的O-乙酰基 - 负变体的比较表明，在成人中，两种类型C组多糖是类似的免疫原性。

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