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首页> 外文期刊>Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine >Relative influence of surface topography and surface chemistry on cell response to bone implant materials. Part 2: biological aspects
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Relative influence of surface topography and surface chemistry on cell response to bone implant materials. Part 2: biological aspects

机译：表面形貌和表面化学对细胞对骨植入材料反应的相对影响。第2部分：生物学方面

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摘要

A current medical challenge is the replacement of tissue which can be thought of in terms of bone tissue engineering approaches. The key problem in bone tissue engineering lies in associating bone stem cells with material supports or scaffolds that can be implanted in a patient. Beside bone tissue engineering approaches, these types of materials are used daily in orthopaedics and dental practice as permanent or transitory implants such as ceramic bone filling materials or metallic prostheses. Consequently, it is essential to better understand how bone cells interact with materials. For several years, the current authors and others have developed in vitro studies in order to elucidate the mechanisms underlying the response of human bone cells to implant surfaces. This paper reviews the current state of knowledge and proposes future directions for research in this domain.
机译：当前的医学挑战是可以根据骨组织工程学方法来考虑组织的替换。骨组织工程中的关键问题在于将骨干细胞与可以植入患者体内的材料支撑物或支架相关联。除了骨组织工程方法外，这些类型的材料还每天在骨科和牙科诊所中用作永久性或暂时性植入物，例如陶瓷骨填充材料或金属假体。因此，必须更好地了解骨细胞如何与材料相互作用。几年来，当前的作者和其他人已经开展了体外研究，以阐明人类骨细胞对植入物表面反应的潜在机制。本文回顾了当前的知识状态，并提出了该领域研究的未来方向。

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