Metabolism of inorganic arsenic and non-cancerous health hazards associated with chronic exposure in humans

Chin-Hsiao Tseng

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Metabolism of inorganic arsenic and non-cancerous health hazards associated with chronic exposure in humans

机译：与人体长期接触有关的无机砷和非癌性健康危害的代谢

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Humans can be exposed to arsenic from a variety of environmental, occupational and medicinal sources. Exposure from drinking water is the most common source nowadays. Inorganic arsenic is metabolized by two main biochemical reactions: reduction and oxidative methylation. Recent studies have confirmed a reactivation of the toxic effects of arsenic associated with such methylation process, because the methylated metabolites, especially the trivalent forms, are more toxic than the inorganic arsenicals. Chronic exposure to arsenic can cause a variety of cancerous and non-cancerous health hazards in humans. The main non-cancerous health hazards include cardiovascular disease, skin lesions, neurological problems, diabetes mellitus and hypertension.

机译：人类可能会从各种环境，职业和医学来源接触砷。如今，饮用水是最常见的来源。无机砷通过两个主要的生化反应代谢：还原和氧化甲基化。最近的研究证实了与这种甲基化过程相关的砷的毒性作用的重新激活，因为甲基化的代谢物，尤其是三价形式的毒性比无机砷更具毒性。长期暴露于砷中会导致人类罹患各种癌性和非癌性健康危害。主要的非癌性健康危害包括心血管疾病，皮肤损害，神经系统问题，糖尿病和高血压。

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来源
《Journal of environmental biology》 |2007年第2s期|p.349-357|共9页
作者
Chin-Hsiao Tseng;
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作者单位

Division of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipai, Taiwan;

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原文格式 PDF
正文语种 eng
中图分类环境生物学;
关键词
inorganic arsenic; human exposure; health hazards; blackfoot disease; neuropathy;

机译：无机砷;人体暴露;健康危害;黑脚病;神经病;

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1. Considerations when using longitudinal cohort studies to assess dietary exposure to inorganic arsenic and chronic health outcomes [J] . Scrafford Carolyn G., Barraj Leila M., Tsuji Joyce S. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research . 2016,第Null期

机译：使用纵向队列研究评估饮食对无机砷和慢性健康结局的影响时的注意事项
2. Chronic inorganic arsenic exposure in vitro induces a cancer cell phenotype in human peripheral lung epithelial cells [J] . Person Rachel J., Ngalame Ntube N. Olive, Makia Ngome L., Toxicology and Applied Pharmacology . 2015,第1期

机译：体外慢性砷暴露在人外周肺上皮细胞中诱导癌细胞表型
3. Evaluation of gene expression changes in human primary lung epithelial cells following 24-hr exposures to inorganic arsenic and its methylated metabolites and to arsenic trioxide [J] . Efremenko Alina Y., Seagrave JeanClare, Clewell Harvey J., Environmental and molecular mutagenesis. . 2015,第5期

机译：暴露于无机砷及其甲基化代谢产物和三氧化二砷24小时后，人原代肺上皮细胞基因表达变化的评估
4. Chronic Inorganic Arsenic Exposure Alters Heme Metabolism in Humans [C] . Luz Maria Del Razo, Carolina Aguilar, Mariano E. Cebrian, International conference on arsenic exposure and health effects . 2001

机译：慢性无机砷暴露在人类中改变血红蛋作
5. The human health risks of lead and inorganic arsenic exposures from consuming home-produced garden vegetables. [D] . Bacigalupo, Christopher. 2006

机译：食用家庭自制的花园蔬菜会导致铅和无机砷暴露对人类健康的风险。
6. Metabolism of inorganic arsenic in children with chronic high arsenic exposure in northern Argentina. [O] . G Concha, B Nermell, M V Vahter 1998

机译：阿根廷北部慢性高砷暴露儿童的无机砷代谢。
7. Metabolism of inorganic arsenic in children with chronic high arsenic exposure in northern Argentina. [O] . Concha, G, Nermell, B, Vahter, M V 1998

机译：阿根廷北部慢性高砷暴露儿童的无机砷代谢。
8. Metabolism and Disposition of Inorganic Arsenic in Laboratory Animals and Humans. [R] . McKinney, J. D. 1992

机译：实验动物和人类中无机砷的代谢和配置。

Metabolism of inorganic arsenic and non-cancerous health hazards associated with chronic exposure in humans

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