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首页> 外文期刊>Journal of environmental science and health >Change in the antimicrobial resistance profile of Pseudomonas aeruginosa from soil after exposure to herbicides
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Change in the antimicrobial resistance profile of Pseudomonas aeruginosa from soil after exposure to herbicides

机译：暴露于除草剂后铜绿假单胞菌对土壤的抗药性变化

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摘要

The extensive use of pesticides represents a risk to human health and to the environment. This study aimed to investigate if the exposure to atrazine and diuron, two herbicides widely used in Brazil, could induce changes in the susceptibility profile to aztreonam, colistin and polymyxin B antimicrobials in isolates of P. aeruginosa obtained from soil samples by using the determination of minimum inhibitory concentration (MIC) test. Three isolates had an increase of MIC to aztreonam after exposure to both herbicides and one isolate did not show any MIC change. The MexAB-OprM efflux pump has already been upregulated in these isolates and the herbicides atrazine and diuron did not increase MexAB-OprM overexpression. Therefore, the decrease in aztreonam susceptibility was not directly related to this pump, suggesting that probably other mechanisms should be involved.
机译：农药的广泛使用对人体健康和环境构成威胁。这项研究旨在调查暴露于土壤样品中的铜绿假单胞菌分离株是否暴露于巴西广泛使用的两种除草剂阿特拉津和杜隆，它们是否能诱导对铜绿假单胞菌，大肠菌素和多粘菌素B抗菌剂的敏感性变化。最低抑菌浓度（MIC）测试。暴露于两种除草剂后，三株分离株的氨曲南的MIC增加，而一株未显示MIC变化。这些分离物中的MexAB-OprM外排泵已被上调，除草剂at去津和杜伦没有增加MexAB-OprM的过表达。因此，氨曲南敏感性的降低与该泵并不直接相关，表明可能还应涉及其他机制。

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