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首页> 外文期刊>Journal of environmental science and health >Toxicity Of Lindane (γ-hexachloroxiclohexane) In Sparus Aurata, Crassostrea Angulata And Scrobicularia Plana
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Toxicity Of Lindane (γ-hexachloroxiclohexane) In Sparus Aurata, Crassostrea Angulata And Scrobicularia Plana

机译：林丹（γ-六氯环已烷）对灵芝，景天，圆盘菌的毒性

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摘要

The purpose of the present study was to research the sublethal and/or lethal effects produced by the exposure of fish and shellfish to the γ isomer of lindane, γ-hexachlorocyclohexane (γ-HCH). The teleostean fish Sparus aurata and the shellfish Crassostrea angulata and Scrobicularia plana, were exposed to 16 μg/L of lindane for 15 days. Samples of different fish (liver, kidney and gills) and shellfish (gills, gut, digestive gland and mantle) tissues were extracted and processed for histopathological observations. Although mortality was not detected during the bioassay, sublethal effects (histopathological alterations) were observed. Vacuolization in the liver cells and lamellar fusion in gills from exposed fish were observed. Disorganization of normal gill structure, epithelial desquamation with the disappearance of apical ciliature in intestine, and inflammatory response in mantle from exposed shellfish were also observed. Thus, it can be concluded that the lindane concentration employed in the present research did not produce lethal effects in the exposed organisms but it caused sublethal effects. Lindane has time-dependent multiple toxic effects in S. aurata, C. angulata and S. plana, which were more severe at the end of the experimental time. The toxicological implications arising from these results are subjects for further multiconcentration tests dealing with lethal responses (mortality) or with sublethal responses (cellular/molecular biomarkers) of the aforementioned species.
机译：本研究的目的是研究鱼和贝类与林丹的γ异构体γ-六氯环己烷（γ-HCH）接触所产生的亚致死作用和/或致死作用。将硬骨鱼类Sparus aurata和贝类Crassostrea angulata和Scrabicularia暴露于16μg/ L的林丹中15天。提取不同鱼类（肝，肾和腮）和贝类（腮，肠，消化腺和地幔）组织的样品，并进行组织病理学观察。尽管在生物测定过程中未检测到死亡率，但观察到了亚致死作用（组织病理学改变）。观察到暴露鱼的肝细胞中有真空化和and中的层状融合。还观察到正常g结构紊乱，上皮脱皮以及肠道顶端纤毛消失，以及暴露贝类的地幔发炎反应。因此，可以得出结论，本研究中使用的林丹浓度在暴露的生物体中没有产生致死作用，但引起了亚致死作用。林丹对S. aurata，C。angulata和S. Plana具有时效性多重毒性作用，在实验时间结束时更为严重。从这些结果产生的毒理学意义是涉及上述物种的致死反应（死亡率）或亚致死反应（细胞/分子生物标志物）的进一步多浓度测试的对象。

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