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首页> 外文期刊>Journal of environmental science and health >Toxic Effects Of Chlorpromazine On Carassius Auratus And Its Oxidative Stress
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Toxic Effects Of Chlorpromazine On Carassius Auratus And Its Oxidative Stress

机译：氯丙嗪对Car鱼的毒性作用及其氧化应激

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摘要

Under laboratory conditions, ecotoxicological effects of chlorpromazine (CPZ) on freshwater goldfish (Carassius auratus) were examined using the toxic culture experiment. The results showed that the median lethal concentration (LC_(50)) of CPZ toxic to Carassius auratus in 24, 48 and 96 h was 1.11, 0.43 and 0.32 mg/L, respectively. Thus, CPZ is an extreme toxicant to goldfish. Furthermore, there were significantly positive correlations between the ecotoxicological effects of CPZ and its concentrations, and the toxicity became higher as the exposure time increased. The activity of superoxide dismutase (SOD) and catalase (CAT) in goldfish livers was significantly influenced by CPZ. At the same exposure time, the activity of SOD reduced first, and increased then, whereas the activity of CAT enhanced first and decreased then. At the same exposure levels of CPZ, the activity of SOD and CAT changed similarly, decreased first, then increased and decreased at last. Within the range of exposure concentrations, the changes in the activity of CAT can more easily reflect the oxidation stress in Carassius auratus by CPZ than those of SOD.
机译：在实验室条件下，使用毒性培养实验检查了氯丙嗪（CPZ）对淡水金鱼（Car鱼）的生态毒理作用。结果表明，在24、48和96 h内，对Z鱼有毒的CPZ的中位致死浓度（LC_（50））分别为1.11、0.43和0.32 mg / L。因此，CPZ对金鱼具有极高的毒性。此外，CPZ的生态毒理学效应与其浓度之间存在显着的正相关关系，并且随着暴露时间的增加，毒性变得更高。 CPZ显着影响金鱼肝脏中的超氧化物歧化酶（SOD）和过氧化氢酶（CAT）的活性。在相同的暴露时间，SOD的活性先降低，然后增加，而CAT的活性先升高，然后降低。在相同的CPZ暴露水平下，SOD和CAT的活性类似地变化，先降低，然后再升高和降低。在暴露浓度范围内，与SOD相比，CPZ的CAT活性变化更容易反映CPZ对Car鱼的氧化应激。

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