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首页> 外文期刊>Journal of environmental science and health >Bendiocarbamate induced structural alterations in rabbit thymus after experimental peroral administration
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Bendiocarbamate induced structural alterations in rabbit thymus after experimental peroral administration

机译：经口经口给药后苯达氨基甲酸酯引起兔胸腺结构改变

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摘要

In this study histological structure of rabbit thymus after bendiocarbamate (2,3-isopropyledene―dioxyphenyl methylcarbamate) administration was studied. Bendiocarbamate was perorally administered for 90 days. At Day 3, 10, 20, 30, 60, 90 morphometric analysis was realized. Quantitative evaluation showed that in the control group thymus cortex forms 57.94 ± 7.10% and medulla 35.94 ± 7.38%. In almost all experimental groups significantly higher relative volume of cortex and lower relative volume of medulla was detected. Detail morphometric analysis found that the number of thymocytes per constant area and the diameter of tymocytes was decresed after bendiocarbamate administration. The number and diameter of reticular cells was not affected. Results of this study suggest negative effect of bendiocarbamate on the formation of thymus structures.
机译：本研究研究了苯达氨基甲酸酯（2,3-异丙基戊二烯基-二氧苯基甲基氨基甲酸酯）给药后兔胸腺的组织学结构。口服苯二甲氨基甲酸酯90天。在第3、10、20、30、60、90天进行了形态分析。定量评估显示，在对照组中，胸腺皮层占57.94±7.10％，髓质占35.94±7.38％。在几乎所有实验组中，皮质的相对体积和髓质的相对体积均显着较高。详细的形态计量学分析发现，苯达氨基甲酸酯给药后，每恒定面积的胸腺细胞数量和胸腺细胞直径减少。网状细胞的数量和直径不受影响。这项研究的结果表明，苯达氨基甲酸酯对胸腺结构的形成具有负面影响。

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