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首页> 外文期刊>Journal of Environmental Science and Health >The antimicrobial agents triclocarban and triclosan as potent modulators of reproduction in Potamopyrgus antipodarum (Mollusca: Hydrobiidae)
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The antimicrobial agents triclocarban and triclosan as potent modulators of reproduction in Potamopyrgus antipodarum (Mollusca: Hydrobiidae)

机译：抗菌剂三氯卡班和三氯生是有效的调节器（Potamopyrgus antipodarum）的软体动物（软体动物：Hydrobiidae）

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摘要

In this study, we assessed the chronic effects of the two antimicrobial substances triclocarban (TCC) and triclosan (TCS) on reproduction of a mollusk species by using the reproduction test with the New Zealand mudsnail Potamopyrgus antipodarum. Snails coming from a laboratory culture were exposed for 28days to nominal concentrations ranging from 0.1 up to 10 mu g/L for both chemicals (measured 0.082-8.85 mu g TCC/L; 0.068-6.26 mu g TCS/L). At the end of the experiment, snails were dissected and embryos in the brood pouch were counted to assess the individualized reproductive success of adult snails. Exposure to TCC resulted in an inverted u-shaped concentration-response relationship, with a stimulation of reproduction at low concentrations followed by an inhibition at higher concentrations. The no observed effect concentration (NOEC) and the lowest observed effect concentration (LOEC) were 0.082 and 0.287 mu g/L, respectively. TCS caused significantly increased embryo numbers at all tested concentrations, except in the group of 0.170 mu g/L. Therefore, the NOEC for TCS was 0.170 mu g/L and the LOEC was 0.660 mu g/L. These results indicate that TCC and TCS may cause reproductive effects at environmentally relevant concentrations indicating a potential risk for aquatic organisms in the environment.
机译：在这项研究中，我们使用新西兰泥nail Potamopyrgus antipodarum的繁殖测试，评估了三种抗菌物质三氯卡班（TCC）和三氯生（TCS）对软体动物物种的繁殖的慢性影响。将来自实验室培养的蜗牛暴露于两种化学药品的标称浓度范围为0.1至10μg / L 28天（测量值为0.082-8.85μgTCC / L； 0.068-6.26μgTCS / L）。在实验结束时，解剖蜗牛并计数育雏袋中的胚胎，以评估成年蜗牛个体化的繁殖成功率。暴露于TCC导致倒U型浓度-反应关系，低浓度刺激繁殖，高浓度则受到抑制。无观察到的浓度（NOEC）和最低观察到的浓度（LOEC）分别为0.082和0.287μg / L。在所有测试浓度下，TCS导致胚胎数量显着增加，但在0.170μg / L组除外。因此，TCS的NOEC为0.170μg / L，LOEC为0.660μg / L。这些结果表明，TCC和TCS在与环境有关的浓度下可能引起生殖作用，表明对环境中水生生物的潜在危险。

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