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首页> 外文期刊>Journal of Environmental Science and Health >Chronic lung disease and detection of pulmonary artery dilatation in high resolution computerized tomography of chest in chronic arsenic exposure
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Chronic lung disease and detection of pulmonary artery dilatation in high resolution computerized tomography of chest in chronic arsenic exposure

机译：慢性砷暴露的高分辨率胸部X线计算机断层扫描术中的慢性肺疾病和肺动脉扩张的检测

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摘要

Lung affection in chronic arsenicosis developing from chronic ingestion of arsenic contaminated groundwater has been known but little is known on its effect on pulmonary arterial system. A cross sectional study was carried out at two geographically similar areas and demographically similar populations with or without evidence of chronic arsenic exposure in West Bengal, India. The willing participants in both the groups with chronic respiratory symptoms were evaluated with High Resolution Computerized Tomography (HRCT) of Chest. Evaluation of High Resolution Computerized Tomography of chest followed clinical assessment of lung disease inl94 and 196 subjects from the arsenic exposed and unexposed people; the former had a higher prevalence of cough OR(Odds Ratio) 3.23 (95% CI(Confidence Interval): 1.72-6.07) and shortness of breath OR1.76 (95% CI: 0.84-3.71), respectively. The arsenic exposed individuals showed higher score for bronchiectasis [mean ± SD(Standard Deviation)] as 2.41 ± 2.32 vs. 1.22 ± 1.48 (P ＜0.001), pulmonary artery branch dilatation (PAD) as 2.48 ± 2.33 vs. 0.78 ± 1.56, (P ＜0.001) and pulmonary trunk dilatation as 0.26 ± 0.45 vs. nil. Age-adjusted prevalence odds ratio (POR) for Pulmonary Artery Dilatation Found in HRCT comparing those exposed to arsenic (Group 1) to unexposed participants (Group 2) was found to be 6.98 (CI: 2.26-16.48). There was a strong dose-response relationship between the PAD (Pulmonary Artery Dilatation) and cumulative arsenic exposure. Pulmonary trunk and branch dilatation in chronic arsenicosis is a frequent abnormality seen in HRCT Chest of arsenicosis patients. The significance of such finding needs further investigation.
机译：长期摄入砷污染的地下水会导致慢性砷中毒引起肺部感染，但对肺动脉系统的影响知之甚少。在印度西孟加拉邦的两个地理相似的地区和人口相似的人群中进行了横断面研究，无论有没有慢性砷暴露的迹象。两组有慢性呼吸系统症状的自愿参与者均通过胸部高分辨率计算机断层扫描（HRCT）进行了评估。评估高分辨计算机断层扫描技术后，对94名和196名来自砷暴露和未暴露人群的受试者的肺部疾病进行了临床评估；前者的咳嗽流行率OR（比值比）较高，分别为3.23（95％CI（置信区间）：1.72-6.07）和呼吸急促OR1.76（95％CI：0.84-3.71）。暴露于砷的个体在支气管扩张方面的平均得分较高（平均值±标准差）为2.41±2.32比1.22±1.48（P ＜0.001），肺动脉分支扩张度（PAD）为2.48±2.33比0.78±1.56， （P ＜0.001）和肺干扩张为0.26±0.45 vs.无。在HRCT中发现，将暴露于砷（第1组）与未暴露的参与者（第2组）的人群进行年龄调整后的患病肺动脉扩张比值比（POR）为6.98（CI：2.26-16.48）。 PAD（肺动脉扩张）和累积砷暴露之间存在强烈的剂量反应关系。慢性砷中毒患者的肺干和分支扩张是砷中毒患者的HRCT胸部常见的异常现象。这种发现的意义需要进一步调查。

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