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首页> 外文期刊>Journal of Environmental Science and Health >Degradation of paracetamol by Pseudomonas aeruginosa strain HJ1012
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Degradation of paracetamol by Pseudomonas aeruginosa strain HJ1012

机译：铜绿假单胞菌菌株HJ1012降解扑热息痛

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摘要

Pseudomonas aeruginosa strain HJ1012 was isolated on paracetamol as a sole carbon and energy source. This organism could completely degrade paracetamol as high as 2200 mg/L. Following paracetamol consumption, a CO_2 yield rate up to 71.4% proved that the loss of paracetamol was mainly via mineralization. Haldane's equation adequately described the relationship between the specific growth rate and substrate concentration. The maximum specific growth rate and yield coefficient were 0.201 g-Paracetamol/g-VSS·h and 0.101 mg of biomass yield/mg of paracetamol consumed, respectively. A total of 8 metabolic intermediates was identified and classified into aromatic compounds, carboxylic acids, and inorganic species (nitrite and nitrate ions). P-aminophenol and hydroquinone are the two key metabolites of the initial steps in the paracetamol catabolic pathway. Paracetamol is degraded predominantly via p-aminophenol to hydroquinone with subsequent ring fission, suggesting partially new pathways for paracetamol-degrading bacteria.
机译：在扑热息痛中分离出铜绿假单胞菌菌株HJ1012作为唯一碳和能源。这种生物可以完全降解高达2200 mg / L的扑热息痛。扑热息痛消费后，CO_2产率高达71.4％，证明扑热息痛的损失主要是通过矿化作用。霍尔丹方程充分描述了比生长速率与底物浓度之间的关系。最大比生长速率和产量系数分别为0.201 g-对乙酰氨基酚/ g-VSS·h和0.101 mg生物量产量/ mg对乙酰氨基酚消耗。总共鉴定出8种代谢中间体，并将其分类为芳族化合物，羧酸和无机物（亚硝酸根和硝酸根离子）。对氨基苯酚和对苯二酚是对乙酰氨基酚分解代谢途径初始步骤的两个关键代谢产物。扑热息痛主要通过对氨基苯酚降解为对苯二酚，随后发生环裂变，提示对乙酰氨基酚降解细菌有部分新途径。

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  • 来源
    《Journal of Environmental Science and Health》 |2013年第8期|791-799|共9页
  • 作者

    JUN HU; LI L. ZHANG; JIAN M. CHEN; YU LIU;

  • 作者单位

    School of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou, China;

    School of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou, China State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China;

    School of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou, China;

    Division of Environmental and Water Resources Engineering, School of Civil and Environmental Engineering, National Taiwan Ocean University, Nanyang Technological University, Singapore;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Paracetamol; biodegradation; Pseudomonas aeruginosa strain HJ1012; mineralization; kinetics; metabolic pathway;

    机译：扑热息痛;生物降解铜绿假单胞菌菌株HJ1012;矿化动力学;代谢途径;

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