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首页> 外文期刊>Journal of Environmental Science and Health >Evaluation of dietary arsenic exposure and its biomarkers: A case study of West Bengal, India
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Evaluation of dietary arsenic exposure and its biomarkers: A case study of West Bengal, India

机译：饮食中砷暴露及其生物标志物的评估：以印度西孟加拉邦为例

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摘要

Few reports are available that characterize daily arsenic exposure through water and diet among people living in groundwater-contaminated regions and correlate it with biomarkers. The present study describes the total individual arsenic exposure and arsenic level in urine and hair of such an arsenic-exposed population in West Bengal. Demographic characteristics and the total daily arsenic intake through water and diet were determined in 167 (Group-1 participants selected from arsenic endemic region) and 69 (Group-2 participants selected from arsenic non-endemic region) in West Bengal. Out of 167 Group-1 participants 78 (Group-1 A) had arsenical skin lesions while 89 Group-IB) had no such lesion. Arsenic level in water samples as well as diet, urine and hair samples, collected from all the individual participants, were estimated. The mean value of estimated total arsenic content from water and diet was 349 (range: 20-1615) p.g/day in 167 (Group-1) participants living in As endemic region [As in water: mean value 54 (range:BDL-326) μg/L] and 36 (range: 12-120) μg/day in 69 (Group-2) participants living in As non-endemic region (As in water: below detection level (BDL), ＜ 0.3 μg/L). Estimated mean arsenic level in urine in these two groups of participants was 116 (range: 6-526) μg/L and 17 (range: BDL-37) μg/L and in hair was 1.0 (range: 0.22-3.98) mg/Kg and 0.16 (range: 0.06-0.37) mg/Kg, respectively. Multiple regressions analysis in Group-1 participants showed that total arsenic intake was associated significantly with urinary and hair arsenic level. The estimated regression coefficient was 0.0022 (95% confidence interval, C.I: 0.0016, 0.0028; P ＜ 0.001) and 0.0024 (95% C.I: 0.0021, 0.003; P ＜ 0.001), respectively. In sub group analysis, higher median urinary arsenic value relative to arsenic intake through water and diet was observed in 78 Group-1 A subjects with skin lesion compared to urinary arsenic value in 89 Group-IB subjects without skin lesions, though there was a marginal difference of median total arsenic intake in these two groups. This study showed that significant elevation of arsenic level in urine and hair was associated with elevated arsenic intake through water and diet in people living in arsenic endemic region (Group-1), while these values were low in people living in non-endemic region (Group-2). Those with skin lesions were found to have higher arsenic in urine and hair compared to those without skin lesion with similar arsenic intake through water and diet.
机译：很少有报告能描述生活在地下水污染地区的人们通过水和饮食每天接触砷的特征，并将其与生物标志物联系起来。本研究描述了西孟加拉邦这种砷暴露人群的总砷暴露量以及尿液和头发中的砷含量。在西孟加拉邦的167位（第1组参与者选自砷地方病地区）和69位（第2组参与者从砷非地方病地区）确定了人口统计学特征以及通过水和饮食摄入的每日总砷。在167名第1组参与者中，有78名（第1 A组）患有砷性皮肤病变，而89名第1组（IB组）没有此类病变。估计了从所有参与者中收集的水样以及饮食，尿液和头发中的砷含量。在生活在地方病地区的167名（第1组）参与者中，估计的水和饮食中总砷含量的平均值为349（范围：20-1615）pg /天[在水中：平均值为54（范围：BDL- 326）μg/ L]和69（第2组）参与者中的36（范围：12-120）μg/天，生活在非流行地区（如在水中：低于检测水平（BDL），＜0.3μg/ L ）。两组参与者的尿中砷平均含量估计为116（范围：6-526）μg/ L和17（范围：BDL-37）μg/ L，头发中的砷平均含量为1.0（范围：0.22-3.98）mg / L Kg和0.16（范围：0.06-0.37）mg / Kg。 1组参与者的多元回归分析表明，总砷摄入量与尿液和头发中的砷含量显着相关。估计的回归系数分别为0.0022（95％置信区间，C.I：0.0016、0.0028； P ＜0.001）和0.0024（95％C.I：0.0021、0.003； P ＜0.001）。在亚组分析中，相对于通过水和饮食摄入的砷，在78名具有皮肤病变的A-1 A组受试者中观察到较高的尿中砷值，而在89名无皮肤损伤的IB-IB组受试者中，尿砷的中位数高于边缘两组中砷的总摄入量的差异。这项研究表明，生活在砷流行地区（第1组）的人通过尿液和饮食中砷和尿液中砷含量的显着升高与摄入水和饮食中砷的摄入增加有关，而在非流行地区（生活水平较高）的人中砷含量较低（组2）。与没有皮肤病的人相比，那些有皮肤病的人尿和头发中的砷含量较高，而通过水和饮食摄入的砷量相似。

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