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首页> 外文期刊>Journal of Environmental Science and Health >Zinc oxide nanoparticles cause nephrotoxicity and kidney metabolism alterations in rats
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Zinc oxide nanoparticles cause nephrotoxicity and kidney metabolism alterations in rats

机译：氧化锌纳米颗粒导致大鼠肾毒性和肾脏代谢改变

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摘要

Although zinc oxide nanoparticles (ZnO NPs) have been widely used, their potential hazards on mammalian and human remain largely unknown. In this study, the biochemical compositions of urine and kidney from the rats treated with ZnO NPs (100, 300 and 1000 mg/kg, respectively) were investigated using 'H nuclear magnetic resonance (NMR) technique with the pattern recognition of partial least squares-discriminant analysis. Hematology, clinical biochemistry and kidney histopathological examinations were also performed. Metabolic profiles from rats treated with ZnO NPs exhibited increases in the levels of taurine, lactate, acetate, creatine, phosphocholine, trimethylamine-N-oxide, α-glucose, and 3-D-hydroxybutyrate, as well as decreases in lipid, succinate, citrate, α-ketoglutarate, hippurate and 4-hydroxyphenylacetic acid in urine after ZnO NPs treatment for 14 days. A similar alteration pattern was also identified in kidney. Urine choline and phosphocholine increased significantly shortly after ZnO NPs treatment, moreover, some amino acids and glucose also increased during the experimental period. However, succinate, citrate and α-ketoglutarate in urine exhibited a different alteration trend, which showed increases on the first day after ZnO NPs treatment, but decreases gradually until the termination of the study. A similar alteration pattern of urinary 'H NMR spectra was also detected in kidney. Moreover, ZnO NPs (1000 mg/kg) resulted in significant increases in serum creatine and blood urea nitrogen, decreases in hemoglobin, haematocrit and mean corpuscular hemoglobin concentration, and overt tubular epithelial cell necrosis. These findings show that ZnO NPs can disturb the energy metabolism and cause mitochondria and cell membrane impairment in rat kidney, which may contribute to ZnO NPs-induced nephrotoxicity.
机译：尽管氧化锌纳米颗粒（ZnO NPs）已被广泛使用，但它们对哺乳动物和人类的潜在危害仍然未知。在这项研究中，使用'H核磁共振（NMR）技术以部分最小二乘模式识别，研究了ZnO NPs（分别为100、300和1000 mg / kg）处理的大鼠尿液和肾脏的生化组成。判别分析。还进行了血液学，临床生化和肾脏组织病理学检查。用ZnO NPs处理的大鼠的代谢曲线显示牛磺酸，乳酸，乙酸盐，肌酸，磷酸胆碱，三甲胺-N-氧化物，α-葡萄糖和3-D-羟基丁酸酯的含量增加，脂质，琥珀酸酯， ZnO NPs治疗14天后尿液中的柠檬酸，α-酮戊二酸，马尿酸和4-羟苯乙酸。在肾脏中也发现了类似的改变模式。 ZnO NPs处理后不久，尿胆碱和磷胆碱显着增加，而且在实验期间一些氨基酸和葡萄糖也增加。然而，尿液中的琥珀酸盐，柠檬酸盐和α-酮戊二酸表现出不同的变化趋势，在ZnO NPs处理后的第一天有所增加，但逐渐下降直至研究终止。在肾脏中也检测到尿'1 H NMR谱的类似变化模式。此外，ZnO NPs（1000 mg / kg）导致血清肌酸和血尿素氮显着增加，血红蛋白，血细胞比容和平均红细胞血红蛋白浓度降低，以及明显的肾小管上皮细胞坏死。这些发现表明，ZnO NPs可以干扰大鼠肾脏的能量代谢并引起线粒体和细胞膜损伤，这可能是ZnO NPs引起的肾毒性的原因。

著录项

  • 来源
    《Journal of Environmental Science and Health》 |2012年第4期|p.577-588|共12页
  • 作者

    GUANGYAN YAN; YINA HUANG; QIAN BU; LEI LV; PENGCHI DENG; JIAQING ZHOU; YANLI WANG; YANZHU YANG; QIANGQIANG LIU; XIAOBO CEN; YINGLAN ZHAO;

  • 作者单位

    National Key Lab ofBiotherapy, West China Hospital of Sichuan University, Chengdu, China,National Chengdu Center for Safety Evaluation of Drugs, West China Hospital of Sichuan University, Chengdu, China;

    National Key Lab ofBiotherapy, West China Hospital of Sichuan University, Chengdu, China,National Chengdu Center for Safety Evaluation of Drugs, West China Hospital of Sichuan University, Chengdu, China;

    National Key Lab ofBiotherapy, West China Hospital of Sichuan University, Chengdu, China,National Chengdu Center for Safety Evaluation of Drugs, West China Hospital of Sichuan University, Chengdu, China;

    National Key Lab ofBiotherapy, West China Hospital of Sichuan University, Chengdu, China,National Chengdu Center for Safety Evaluation of Drugs, West China Hospital of Sichuan University, Chengdu, China;

    Analytical &Testing Center, Sichuan University, Chengdu, China;

    National Chengdu Center for Safety Evaluation of Drugs, West China Hospital of Sichuan University, Chengdu, China;

    Sichuan Women and Children's Hospital, Chengdu, China;

    National Key Lab ofBiotherapy, West China Hospital of Sichuan University, Chengdu, China,National Chengdu Center for Safety Evaluation of Drugs, West China Hospital of Sichuan University, Chengdu, China;

    National Chengdu Center for Safety Evaluation of Drugs, West China Hospital of Sichuan University, Chengdu, China;

    National Key Lab ofBiotherapy, West China Hospital of Sichuan University, Chengdu, China,National Chengdu Center for Safety Evaluation of Drugs, West China Hospital of Sichuan University, Chengdu, China;

    National Key Lab ofBiotherapy, West China Hospital of Sichuan University, Chengdu, China,National Key Lab of Biotherapy, West China Hospital of Sichuan University, #1 Keyuan Road 4, Gaopeng Street, High Technological Development Zone, Chengdu 610041, China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    metabonomic; toxicity; zinc oxide; nanoparticle;

    机译：代谢组学毒性;氧化锌纳米粒子;

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