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首页> 外文期刊>Journal of Environmental Science and Health >Hypertension in chronic arsenic exposure: A case control study in West Bengal
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Hypertension in chronic arsenic exposure: A case control study in West Bengal

机译：慢性砷暴露中的高血压：西孟加拉邦的病例对照研究

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摘要

Various systemic manifestations are reported to be caused by chronic arsenic exposure in the population living in the Indo-Bangladesh subcontinent. This study from West Bengal assesses the likelihood of occurrence of hypertension (HTN) in individuals resident in an area of high groundwater contamination with arsenic (Nadia district) compared to those from a non-contaminated area (Hoogly district) in West Bengal, India. Two hundred and eight study participants (Group 1) were recruited from a cross-sectional study in six villages in the Nadia district and 100 controls (Group 2) from a village in the Hoogly district. The two groups were evenly matched in regard to age and sex. History taking and clinical examination including blood pressure measurement were undertaken in each participant. Water samples from current and previous drinking water sources and hair and urine samples from each participant were collected for estimation of arsenic. The present study shows evidence of increased association of HTN in individuals resident in arsenic endemic region compared to those from a non-endemic region in West Bengal. There were increased odds ratios for HTN [Adjusted Odds Ratio, OR, 2.87 (95 %CI = 1.26-4.83)] in Group- 1 participants compared to Group- 2 people. Within Group 1, there was no difference in prevalence of HTN between those with and without skin lesion. There was a dose-effect relationship seen with increasing cumulative arsenic exposure and arsenic level in hair and HTN in participants living in arsenic endemic region.The findings reported here support an association between arsenic exposure and HTN. More work is needed to characterize the link further.
机译：据报道，印度-孟加拉次大陆人口长期砷暴露引起各种系统性表现。来自西孟加拉邦的这项研究评估了居住在砷含量高的地下水污染地区（纳迪亚区）的居民与印度西孟加拉邦未污染地区（霍格利区）居民相比发生高血压（HTN）的可能性。从Nadia地区六个村庄的横断面研究中招募了208名研究参与者（第1组），从Hoogly地区的一个村庄中招募了100名对照（第2组）。两组在年龄和性别上均等。每个参与者都进行了病史记录和包括血压测量在内的临床检查。收集来自当前和以前的饮用水水源的水样本以及来自每个参与者的头发和尿液样本以估算砷。本研究表明，与来自西孟加拉邦非流行地区的居民相比，砷流行地区的居民中HTN关联性增加。与第2组相比，第1组参与者的HTN [调整后的赔率，OR，2.87（95％CI = 1.26-4.83）]的优势比增加。在第1组中，有和没有皮肤病变的人群中HTN的患病率没有差异。生活在砷病流行地区的参与者中，累积砷暴露量与头发和HTN中砷的含量增加之间存在剂量-效应关系，此处报道的发现支持砷暴露与HTN之间的关联。需要更多的工作来进一步表征链接。

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  • 来源
    《Journal of Environmental Science and Health》 |2012年第11期|p.1514-1520|共7页
  • 作者

    DEBENDRA GUHA MAZUMDER; ISHANIKAR PURKAYASTHA; ALOKE GHOSE; GOUTOMMISTRY; CHANDAN SAHA; ASHOKE K. NANDY; ARABINDA DAS; KUNAL K. MAJUMDAR;

  • 作者单位

    DNGM Research Foundation, Kolkata, India DNGM Research Foundation, 37/C, Block 'B', New Alipore, Kolkata 700053, India;

    DNGM Research Foundation, Kolkata, India;

    DNGM Research Foundation, Kolkata, India;

    Department of Clinical and Experimental Pharmacology, School of Tropical Medicine, Kolkata, India;

    Department of Clinical and Experimental Pharmacology, School of Tropical Medicine, Kolkata, India;

    Department of Clinical and Experimental Pharmacology, School of Tropical Medicine, Kolkata, India;

    Department of Statistics, Acharya Prafulla Ch. College, Kolkata, India;

    Department of Community Medicine, KPC Medical College & Hospital, Jadavpur, Kolkata, India;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    arsenic and hypertension; arsenic in hair; arsenic in unexposed population;

    机译：砷和高血压;头发中的砷;未接触人群中的砷;

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