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首页> 外文期刊>Journal of Environmental Science and Health. A, Toxic/Hazardous Substances & Environmental Engineering >Efficacy of Octolig chromatography as a means of removal of aqueous antibiotics given to premature babies
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Efficacy of Octolig chromatography as a means of removal of aqueous antibiotics given to premature babies

机译：Octolig色谱作为去除早产婴儿含水抗生素的一种方法

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摘要

Reliable information indicated that a half-million prematurely born babies are routinely given antibiotics without evidence of infection. This study is based on a concern that such antibiotics might go into hospital waste systems and lead to antibiotic-resistant bacteria. We tested the removal of selected antibiotics by Octolig, a commercially available supported chelating agent using column chromatography. Five (Caffeine, Ampicillin, Furosemide, Dopamine, and Vancomycin) were selected for study. Ampicillin and Furosemide were quantitatively removed by column chromatography. Dopamine, Caffeine, and Vancomycin were failures. Failures are ascribed to inadequate pK(a) values (<5) for these three antibiotics.
机译：可靠的信息表明，有50万早产婴儿常规接受抗生素治疗而没有感染迹象。这项研究基于这样的担忧，即此类抗生素可能会进入医院的废物系统并导致产生抗药性细菌。我们使用柱色谱法测试了Octolig（一种可商购的支持螯合剂）对选定抗生素的去除。选择了五种（咖啡因，氨苄青霉素，速尿，多巴胺和万古霉素）进行研究。通过柱色谱法定量除去氨苄青霉素和速尿。多巴胺，咖啡因和万古霉素都是失败的。失败归因于这三种抗生素的pK（a）值不足（<5）。

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