• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Environmental Science and Health. A, Toxic/Hazardous Substances & Environmental Engineering >Polycyclic aromatic hydrocarbon (PAH) metabolites in marine fishes as a specific biomarker to indicate PAH pollution in the marine coastal environment
【24h】

Polycyclic aromatic hydrocarbon (PAH) metabolites in marine fishes as a specific biomarker to indicate PAH pollution in the marine coastal environment

机译：海洋鱼类中的多环芳烃（PAH）代谢产物是一种特定的生物标记，表明海洋沿海环境中的PAH污染

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In this study, analysis methods for the PAH metabolites of naphthalene (Na), pyrene (Py) and benzo(a)pyrene (BaP) with different benzo-rings (2-4-5 rings respectively) were developed and the metabolism kinetics of Py and BaP in marine fishes were studied. Two PAH metabolites of Na and Py, namely 1-naphthol (1-OH Na) and 1-hydroxy pyrene (1-OH Py), were determined using the fixed wavelength fluorescence (FF) method, and the BaP metabolite, 3-hydroxy benzo(a)pyrene (3-OH BaP), was determined using reverse-phase HPLC with fluorescence detection. The dose- and time-response of Lateolabrax japonicus to Py metabolites and Sparus macrocephalus to BaP metabolites were studied in order to evaluate the use of PAH metabolites as a means of assessing exposure to PAHs. The results showed that both fishes could be induced to metabolize and eliminate their metabolites in vivo with increasing Py and BaP exposure concentrations in seawater. As Py and BaP concentrations increased, metabolite concentrations in the fish bile also increased. A significant dose-response of biliary PAH metabolites was observed after exposure for 1, 3 and 7 days for Py and 2, 4 and 7 days for BaP, respectively. These results provide the proof necessary for using PAH metabolites in marine fishes as a specific biomarker or early warning signal of PAH pollution in the marine coastal environment.
机译：本研究建立了具有不同苯并环（分别为2-4-5个环）的萘，Na（Py）和苯并（a）py（BaP）的PAH代谢物的分析方法，并研究了其代谢动力学。研究了海水鱼类中的Py和BaP。使用固定波长荧光（FF）方法测定了Na和Py的两种PAH代谢物，即1-萘酚（1-OH Na）和1-羟基pyr（1-OH Py），而BaP代谢物3-羟基苯并（a）re（3-OH BaP），使用带荧光检测的反相HPLC测定。为了评估使用PAH代谢物作为评估暴露于PAHs的手段，研究了日本紫花苜蓿对Py代谢物的剂量和时间响应以及Sparus macrocephalus对BaP代谢物的剂量和时间响应。结果表明，随着海水中Py和BaP暴露浓度的增加，两种鱼类都可以在体内被诱导代谢和消除其代谢产物。随着Py和BaP浓度增加，鱼胆中的代谢物浓度也增加。 Py暴露1、3和7天，BaP暴露2、4和7天后，观察到胆汁PAH代谢产物的剂量反应显着。这些结果提供了在海水鱼类中使用PAH代谢物作为海洋沿海环境中PAH污染的特定生物标记或预警信号的必要证据。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号