Hg(II) Exposure Exacerbates UV-Induced DNA Damage in MRC5 Fibroblasts: A Comet Assay Study

Wendy Bradfield; Andrew Pye; Tim Clifford; Leo Salter; David Gould; Sandra Campbell; Alison Curnow

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Hg(II) Exposure Exacerbates UV-Induced DNA Damage in MRC5 Fibroblasts: A Comet Assay Study

机译：汞（II）暴露加剧了MRC5成纤维细胞中紫外线诱导的DNA损伤：一项彗星试验研究

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When exposed to UVR, MRC5 fibroblasts incubated with mercuric chloride (0-15 μM) for 1 hour show increased DNA damage (as measured by the comet assay) compared to control cells (UVR irradiated but no mercuric chloride). This demonstrates that mercuric chloride and UVR in combination increase DNA damage in a synergistic manner. This may have implications to those exposed to mercury as it suggests that exposure to mercury in the environment may increase sensitivity to sunlight-induced carcinogenesis.

机译：当暴露于UVR时，与对照细胞（UVR辐照但未氯化汞）相比，将MRC5成纤维细胞与氯化汞（0-15μM）孵育1小时显示出DNA损伤（通过彗星试验测定）增加。这表明氯化汞和UVR的组合以协同方式增加了DNA损伤。这可能会对那些接触汞的人产生影响，因为这表明环境中的汞接触可能会增加对阳光诱发的致癌作用的敏感性。

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《Journal of Environmental Science and Health. A, Toxic/Hazardous Substances & Environmental Engineering》 |2006年第2期|p.143-148|共6页
作者
Wendy Bradfield; Andrew Pye; Tim Clifford; Leo Salter; David Gould; Sandra Campbell; Alison Curnow;
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作者单位

Cornwall Dermatology Research, Peninsula Medical School, Knowledge Spa, Royal Cornwall Hospital, Treliske, Truro, Cornwall, UK;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类环境科学、安全科学;
关键词
UV; mercury; comet assay; DNA-damage;

机译：紫外线;汞;彗星分析;DNA损伤;

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Hg(II) Exposure Exacerbates UV-Induced DNA Damage in MRC5 Fibroblasts: A Comet Assay Study

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