Computational Prediction of 7-Ethoxyresorufin-O-Diethylase (EROD) and Luciferase (luc) Inducing Potency for 75 Congeners of Chloronaphthalene

J. Falandysz; T. Puzyn

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Computational Prediction of 7-Ethoxyresorufin-O-Diethylase (EROD) and Luciferase (luc) Inducing Potency for 75 Congeners of Chloronaphthalene

机译：计算预测7-乙氧基试卤灵-O-二乙基酶（EROD）和萤光素酶（luc）诱导75种同类氯的效能

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Based on available toxicological data and matrix of structural descriptors 7-ethoxyresorufin-O-diethylase (EROD) and luciferase (luc) inducing potency for 75 congeners of chloronaphthalene was predicted using quantitative structure– activity relationships (QSAR) strategy. The most active congeners in EROD and luciferase bioassays were CN congeners nos. 75 and 67. Some empirical rules describing toxic PCNs were formulated.

机译：根据现有的毒理学数据和结构描述符的矩阵，使用定量结构-活性关系（QSAR）策略预测了75-同类氯萘的诱导能力，其中7-乙氧基异色蛋白-O-二乙基酶（EROD）和荧光素酶（luc）的诱导能力。 EROD和萤光素酶生物测定中最活跃的同类物是CN同类物。 75和67.制定了一些描述有毒PCN的经验规则。

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《Journal of Environmental Science and Health. A, Toxic/Hazardous Substances & Environmental Engineering》 |2004年第6期|p. 1505-1523|共19页
作者
J. Falandysz; T. Puzyn;
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作者单位

Department of Environmental Chemistry and Ecotoxicology University of Gdask Gdask, Poland;

Department of Environmental Chemistry and Ecotoxicology University of Gdask Gdask, Poland;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类环境科学、安全科学;
关键词
Chloronaphtalenes; Polychlorinated naphtalene; sPCNs; 7-Ethoxyresorufin-O-deethylase; EROD; Luciferase bioassay;

机译：氯萘酚;多氯萘;sPCNs;7-乙氧基试卤灵-O-脱乙基酶;EROD;荧光素酶生物测定;

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Computational Prediction of 7-Ethoxyresorufin-O-Diethylase (EROD) and Luciferase (luc) Inducing Potency for 75 Congeners of Chloronaphthalene

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