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首页> 外文期刊>Journal of Environmental Science and Health. A, Toxic/Hazardous Substances & Environmental Engineering >Elemental Analysis of Soft Plaque and Calcified Plaque Deposits from Human Coronary Arteries and Aorta
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Elemental Analysis of Soft Plaque and Calcified Plaque Deposits from Human Coronary Arteries and Aorta

机译：人冠状动脉和主动脉软斑块和钙化斑块沉积物的元素分析

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Twenty-five samples of soft plaque and calcified plaque deposits from human hearts or aorta were analyzed using inductively coupled plasma-mass spectrometry (ICP-MS). The determined elements were Ca, P, Na, K, Mg, Zn, Cu, Ba, Pb, Fe, Al, Si, and S. Results showed that the concentration of all elements in the soft plaque was at the micromolar level. In the calcified deposits, the concentrations of Ca and P were at least an order of magnitude higher than the soft plaque, but the other elements were at the same order of magnitude. In the calcified plaque the molar ratios of Ca/P suggested that a significant portion existed as hydroxyapatite Ca10(PO4)6(OH)3. However, their absolute concentrations indicated that this compound was not a major component of the plaque although it may play a major role in determining the crystal structure of the deposit. In some samples the Ca/P ratio was too high to conform to hydroxyapatite. In others it was too low. This indicated that both the calcium and phosphorus existed in other chemical forms which varied from sample to sample. In the soft tissue the P level was high indicating it existed primarily in chemical forms other than hydroxyapatite. The presence of homocysteine is often associated with heart disease. However, the low levels of sulfur indicate that although it may be present, it is not a major component of the plaque, but may nevertheless play an important role in its formation.
机译：使用电感耦合等离子体质谱法（ICP-MS）分析了来自人心脏或主动脉的25个软斑和钙化斑沉积物样品。所测定的元素为Ca，P，Na，K，Mg，Zn，Cu，Ba，Pb，Fe，Al，Si和S。结果表明，软菌斑中所有元素的浓度均在微摩尔水平。在钙化沉积物中，Ca和P的浓度至少比软斑块高一个数量级，而其他元素的含量相同。在钙化斑块中，Ca / P的摩尔比表明羟基磷灰石Ca10（PO4）6（OH）3存在很大一部分。然而，它们的绝对浓度表明该化合物不是菌斑的主要成分，尽管它可能在确定沉积物的晶体结构中起主要作用。在某些样品中，Ca / P比太高，无法符合羟基磷灰石。在另一些情况下，它太低了。这表明钙和磷均以其他化学形式存在，其化学性质随样品的不同而不同。在软组织中，P水平很高，表明它主要以除羟基磷灰石之外的化学形式存在。同型半胱氨酸的存在通常与心脏病有关。然而，低水平的硫表明尽管它可能存在，但它不是噬菌斑的主要成分，但在其形成中可能起着重要作用。

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