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首页> 外文期刊>Journal of Environmental Science and Health. A, Toxic/Hazardous Substances & Environmental Engineering >Sensitive detection of antidiabetic compounds and one degradation product in wastewater samples by a new SPE-LC-MS/MS method
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Sensitive detection of antidiabetic compounds and one degradation product in wastewater samples by a new SPE-LC-MS/MS method

机译：通过新的SPE-LC-MS / MS方法对废水样品中的抗糖尿病化合物和一种降解产物的敏感性检测

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摘要

As environment emerging contaminants of anthropogenic origin, antidiabetic drugs are present in the range of high ng/L to ng/mL in the influent and the effluent of the waste water treatment plant (WWTP). The metformin compound is the most used hypoglycemic agent in the world. The aim of this study was to develop a new analytic method, based on solid phase extraction followed by liquid chromatography coupled with mass spectrometric detector (SPE-LC-MS/MS), for identification and quantification of 5 antidiabetic compounds (glibenclamide/glyburide, glimepiride, metformin, glipizide, guanyl urea, gliclazide) and one degradation product (guanyl urea). The investigated environmental samples were the influent and the effluent of four urbans WWTP's. By validating of the analytical method, it was obtained low LOQ's (0.2-4.5 ng/L), satisfactory recovery rates (53.6-116.8%), and corresponding performance parameters: inter-day precision (4.9-8.4%) and reproducibility (11.3-14.6%). The concentrations of antidiabetics were as follow in influent and effluent: metformin 76-2041ng/L and 2-206ng/L, gliclazide (14.1-42.4 ng/L, and 3.3-19.1), glipizide (7.5-11.2 ng/L and 6.5-10ng/L), guanyl urea (6.2-7.3 and 8.3-21.3 ng/L). The efficiency of elimination of the antidiabetics in WWTP's was maximum for metformin (67.6-98.5%), followed, by gliclazide (72.9-78.2%). The lowest elimination efficiency was calculated for glipizide (10.7-13.3%). The guanyl urea undergoes a formation process (74.5-84.2%) in effluent, from the metformin contained in influent.
机译：随着环境的新出现人为来源的污染物，抗糖尿病药物在流入水处理和废水处理厂（WWTP）的流出物中存在高Ng / L至Ng / ml的范围。二甲双胍化合物是世界上使用最常用的低血糖药。本研究的目的是开发一种基于固相提取的新的分析方法，然后偶联与质谱探测器（SPE-LC-MS / MS）偶联，用于鉴定和定量5种抗糖尿病化合物（Glibenclamide / Glybusers，胶林苷，二甲双胍，粘吡吡吡甲醚，胍基尿素，神光醇）和一种降解产物（胍脲）。调查的环境样品是四种URBANS WWTP的流动性和流出物。通过验证分析方法，获得低LOQ（0.2-4.5 Ng / L），令人满意的恢复率（53.6-116.8％），以及相应的性能参数：日常精度（4.9-8.4％）和再现性（11.3 -14.6％）。抗体的浓度在流水和流出物中如下：二甲双胍76-2041ng / L和2-206NG / L，Glipizide（14.1-42.4 ng / L和3.3-19.1），粘嘧啶（7.5-11.2 ng / L和6.5 -10ng / l），胍尿素（6.2-7.3和8.3-21.3 ng / l）。在WWTP中消除抗体的消除效率最多用于二甲双胍（67.6-98.5％），随之而来，由Gliclazide（72.9-78.2％）。针对粘性蛋白（10.7-13.3％）计算最低消除效率。胍脲从流入物中含有的二甲双胍进行流出物进行形成过程（74.5-84.2％）。

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