...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Environmental Science and Health >Common Genetic Variants in the Myeloperoxidase and Paraoxonase Genes and the Related Cancer Risk: A Review
【24h】

Common Genetic Variants in the Myeloperoxidase and Paraoxonase Genes and the Related Cancer Risk: A Review

机译：髓过氧化物酶和对氧磷酶基因的常见遗传变异与相关癌症风险：综述

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Modern approaches in health care are moving toward the model of "personalized medicine." Today, current research in molecular biology and medicine is focused on developing genomic markers with predictive, therapeutic, and prognostic significance. One of the most widespread and significant genomic markers is the single nucleotide polymorphism (SNP), which represents a variation in DNA sequence when a single nucleotide differs between members of a biological species or paired chromosomes in an individual. Antioxidant defense enzymes break down dangerous reactive compounds, called reactive oxygen species, and prevent DNA strand from carcinogen-specific mutations. It is well known that inherited variations in genes that encode antioxidant defense enzymes may modulate individual susceptibility to cancer. In our previous study we have determined the predictive significance of several SNPs of su peroxide dismu-tase (SOD) and glutathione peroxidase gene families in the context of cancer risk. The present review includes a summary and discussion of the current findings evaluating the role of SNPs of the myeloperoxidase (MPO) and paraoxanase (PON) genes in cancer occurrence and development. We suggest that rs2333227 (MPO_ -463G/A) and rs854560 polymorphisms have a great predictive significance; they could probably be utilized as cancer predictors in the future. Also, we recommend further in-depth research for rs11079344 (MPO), rs8178406 (MPO), rs2243828 (MPO), rs662 (POND, rs705379 (PON1), and PON1_304A/G polymorphisms. These SNPs may become significant cancer-associated biomarkers.
机译：现代医疗保健方法正在朝着“个性化医学”的模式发展。今天，分子生物学和医学方面的当前研究集中在开发具有预测，治疗和预后意义的基因组标记。最普遍和最重要的基因组标记之一是单核苷酸多态性（SNP），当一个生物物种的成员或成对染色体中的单个染色体之间的单个核苷酸不同时，它代表DNA序列的变化。抗氧化防御酶可分解危险的反应性化合物（称为反应性氧物种），并防止DNA链发生致癌物特异性突变。众所周知，编码抗氧化防御酶的基因的遗传变异可能会调节个体对癌症的敏感性。在我们之前的研究中，我们确定了过氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶基因家族的几个SNP在癌症风险中的预测意义。本审查包括总结和讨论当前发现评估髓过氧化物酶（MPO）和对氧杂酶（PON）基因的SNPs在癌症发生和发展中的作用。我们认为rs2333227（MPO_ -463G / A）和rs854560多态性具有重要的预测意义；它们可能会在将来用作癌症预测因子。另外，我们建议对rs11079344（MPO），rs8178406（MPO），rs2243828（MPO），rs662（POND，rs705379（PON1）和PON1_304A / G多态性进行进一步的深入研究，这些SNP可能成为与癌症相关的重要生物标记。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号