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首页> 外文期刊>Journal of Experimental Botany >Pathways and fluxes: exploring the plant metabolic network
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Pathways and fluxes: exploring the plant metabolic network

机译：途径和通量：探索植物代谢网络

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The transition from a pathway-centred view of plant metabolism to a network-wide perspective is still incomplete. Further progress in this direction requires tools to facilitate the structural description of the network on the basis of fully annotated genomes, techniques for modelling the properties of the network, and experimental methods for constraining the models and verifying their outputs. It also requires a focus on metabolic flux as the key to understanding the regulation of metabolic activity and the relationship between the inputs and outputs of the network. Progress is being made on several fronts and this Special Issue on ‘Pathways and fluxes: exploring the plant metabolic network’ describes current developments in the genomic reconstruction of metabolic networks, the application of flux-balance analysis to such networks, kinetic modelling, and both steady-state-and non-steady state isotope-based measurements of multiple fluxes in the network of central carbon metabolism. The papers also highlight insights that can be obtained from pathway analysis, particularly in relation to the thermodynamic and kinetic efficiency of the predicted and observed flux distributions.
机译：从以途径为中心的植物新陈代谢到全网范围的转变仍然是不完整的。在这个方向上的进一步发展需要工具，以在完全注释的基因组的基础上促进网络的结构描述，对网络属性进行建模的技术以及用于约束模型和验证其输出的实验方法。它还需要关注代谢通量，这是理解代谢活动的调节以及网络输入与输出之间关系的关键。在几个方面都取得了进展，本“路径与通量：探索植物代谢网络”的特刊描述了代谢网络的基因组重构，通量平衡分析在此类网络中的应用，动力学建模以及两者都在进行中。基于稳态和非稳态同位素的中心碳代谢网络中多个通量的测量值。这些论文还强调了可以从途径分析中获得的见解，特别是与预测和观察到的通量分布的热力学和动力学效率有关的见解。

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