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首页> 外文期刊>Journal of Experimental Botany >A molecular framework for coupling cellular volume and osmotic solute transport control
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A molecular framework for coupling cellular volume and osmotic solute transport control

机译：耦合细胞体积和渗透溶质转运控制的分子框架

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Eukaryotic cells expand using vesicle traffic to increase membrane surface area. Expansion in walled eukaryotes is driven by turgor pressure which depends fundamentally on the uptake and accumulation of inorganic ions. Thus, ion uptake and vesicle traffic must be controlled coordinately for growth. How this coordination is achieved is still poorly understood, yet is so elemental to life that resolving the underlying mechanisms will have profound implications for our understanding of cell proliferation, development, and pathogenesis, and will find applications in addressing the mineral and water use by plants in the face of global environmental change. Recent discoveries of interactions between trafficking and ion transport proteins now open the door to an entirely new approach to understanding this coordination. Some of the advances to date in identifying key protein partners in the model plant Arabidopsis and in yeast at membranes vital for cell volume and turgor control are outlined here. Additionally, new evidence is provided of a wider participation among Arabidopsis Kv-like K+ channels in selective interaction with the vesicle-trafficking protein SYP121. These advances suggest some common paradigms that will help guide further exploration of the underlying connection between ion transport and membrane traffic and should transform our understanding of cellular homeostasis in eukaryotes.
机译：真核细胞利用囊泡运输来扩张以增加膜表面积。壁真核生物的膨胀是由膨胀压力驱动的，膨胀压力主要取决于无机离子的吸收和积累。因此，必须协调地控制离子的摄取和囊泡的运输以促进生长。如何实现这种协调仍然知之甚少，但对生命至关重要，因此解决其基本机制将对我们对细胞增殖，发育和发病机理的理解产生深远影响，并将在解决植物矿物质和水利用方面找到应用面对全球环境变化。转运蛋白和离子转运蛋白之间相互作用的最新发现现在为了解这种配位的全新方法打开了大门。本文概述了迄今为止在鉴定模型植物拟南芥和酵母中关键的蛋白伴侣方面的一些进展，这些蛋白对细胞体积和膨大控制至关重要。此外，新的证据表明拟南芥Kv样K + 通道在与小泡运输蛋白SYP121选择性相互作用中更广泛的参与。这些进展表明了一些常见的范例，这些范例将有助于指导进一步探索离子迁移与膜运输之间的潜在联系，并应改变我们对真核生物细胞稳态的理解。

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