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首页> 外文期刊>Journal of Experimental Botany >Hsp90 canalizes developmental perturbation
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Hsp90 canalizes developmental perturbation

机译：Hsp90促进发育扰动

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摘要

Stochastic processes are intrinsic phenomena that perturb developmental processes. However, the canalization process restricts the magnitude of perturbation and hence the magnitude of morphological variation during development. Heat-shock protein 90 (Hsp90) chaperones are a class of proteins stabilizing a network of ‘client’ proteins that are involved in diverse signal transduction pathways affecting development. Here it is reported that a reduction of Hsp90 gene dose creates canalization perturbations that affect many aspects of Arabidopsis development and results in a plethora of morphological alterations. Hence, Hsp90 restricts stochastic phenomena by minimizing perturbations, thereby canalizing development. It is also shown that morphogenesis is determined by three mutually inter-related parameters: genotype, environment, and time. Hsp90 is involved in the interaction of these three parameters which ultimately affect developmental processes. The amount of phenotypic variation upon the reduction of Hsp90 function could be perceived as adaptive and could have an impact on the evolutionary process.
机译：随机过程是干扰发展过程的内在现象。但是，渠化过程限制了摄动的幅度，因此限制了显影过程中形态变化的幅度。热休克蛋白90（Hsp90）伴侣蛋白是一类稳定“客户”蛋白网络的蛋白，这些蛋白参与影响发育的多种信号转导途径。据报道，Hsp90基因剂量的减少会造成渠化干扰，影响拟南芥发育的许多方面，并导致过多的形态学改变。因此，Hsp90通过最小化扰动来限制随机现象，从而促进了发展。还表明形态发生是由三个相互关联的参数决定的：基因型，环境和时间。 Hsp90参与这三个参数的相互作用，最终影响发育过程。 Hsp90功能降低后的表型变异量可以被认为是适应性的，并且可能对进化过程产生影响。

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