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首页> 外文期刊>Journal of food protection >Two IncHI2 Plasmid-Mediated Colistin-Resistant Escherichia coli Strains from the Broiler Chicken Supply Chain in Zhejiang Province, China
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Two IncHI2 Plasmid-Mediated Colistin-Resistant Escherichia coli Strains from the Broiler Chicken Supply Chain in Zhejiang Province, China

机译：两种InChi2质粒介导的乳突耐药大肠杆菌菌株来自浙江省浙江省肉鸡鸡肉供应链的大肠杆菌菌株

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摘要

Colistin is used as one of the last-resort drugs against lethal infections caused by carbapenem-resistant pathogens of the Enterobacteriaceae family. Enterobacteriaceae bacteria carrying the mcr-1 colistin resistance gene are emerging in livestock and poultry, posing a serious threat to human health. However, there have been few reports about the prevalence and transmission of mcr-1 along the regional chicken supply chain. In this study, the complete sequences of mcr-1-positive Escherichia coli ST2705 and ST206 isolates obtained by screening 129 chilled chicken samples and 251 chicken fecal samples were investigated. Both of these isolates showed resistance to colistin, and importantly, the complete sequence of the mcr-1-positive E. coli ST2705 in China was reported for the first time. The mcr-1 gene was located on the IncHI2 plasmids pTBMCR421 (254,365 bp) and pTBMCR401 (230,964 bp) in strains ECCNB20-2 and ECZP248, respectively. Comparative analysis of mcr-1-bearing IncHI2 plasmids showed a marked similarity, indicating that these plasmids are very common and have the ability to be efficient vehicles for mcr-1 dissemination among humans, animals, and food. Furthermore, an insertion (ISKpn26) in Tn6330 (ISApl 1-mcr-1 -pap2-ISApl 1) was identified in the plasmid pTBMCR401 and then compared; this insertion might affect the adaptability and stability of Tn6330. Taken together, these findings suggest that the IncHI2 plasmid might be a main factor affecting the transmission of mcr-1 in the chicken supply chain and that the genetic context of the mcr-1-bearing IncHI2 plasmid is constantly evolving.
机译：Colistin被用作对肠杆菌族抗性病原体抗菌病原体引起的致死感染的最后一个度假毒药之一。携带MCR-1乳菌素抗性基因的肠杆菌菌细菌正在牲畜和家禽中出现，对人类健康构成严重威胁。然而，沿着区域鸡肉供应链的MCR-1的患病率和传播甚至几乎没有报道。在该研究中，研究了通过筛选129冷却的鸡样和251个鸡肉粪便样品获得的MCR-1阳性大肠杆菌Coli ST2705和ST206分离物的完整序列。这两种分离株都显示出对菌氨酸的抗性，并且重要的是，第一次报道了中国MCR-1阳性大肠杆菌ST2705的完整序列。 MCR-1基因分别位于InChi2质粒PTBMCR421（254,365bp）和PTBMCR401（230,964bp）中，分别在菌株ECCNB20-2和ECZP248中。对MCR-1承载的比较分析表明，这些质粒非常常见，表明这些质粒非常常见，并且能够成为人类，动物和食物中的MCR-1播种的有效载体的能力。此外，在质粒pTBMCR401中鉴定了TN6330中的插入（ISKPN26）（ISAPL 1-MCR-1 -PAP2-ISAPL1），然后比较;该插入可能会影响TN6330的适应性和稳定性。这些研究结果表明，INCHI2质粒可能是影响鸡供应链中MCR-1传递的主要因素，并且MCR-1承载INCHI2质粒的遗传背景不断发展。

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  • 来源
    《Journal of food protection》 |2020年第8期|1402-1410|共9页
  • 作者

    JIANG CHANG; BIAO TANG; YIFEI CHEN; XIAODONG XIA; MINGRONG QIAN; HUA YANG;

  • 作者单位

    Institute of Quality and Standard for Agro-products & State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Zhejiang Academy of Agricultural Sciences Hangzhou Zhejiang 310021 People's Republic of China State Key Laboratory of Microbial Metabolism MOST-USDA Joint Research Center for Food Safety School of Agriculture and Biology Shanghai Jiao Tong University Shanghai 200240 People's Republic of China;

    Institute of Quality and Standard for Agro-products & State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Zhejiang Academy of Agricultural Sciences Hangzhou Zhejiang 310021 People's Republic of China;

    College of Food Science and Engineering Northwest Agriculture and Forestry University Yangling Shaanxi 712100 People's Republic of China;

    College of Food Science and Engineering Northwest Agriculture and Forestry University Yangling Shaanxi 712100 People's Republic of China;

    Institute of Quality and Standard for Agro-products & State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Zhejiang Academy of Agricultural Sciences Hangzhou Zhejiang 310021 People's Republic of China;

    Institute of Quality and Standard for Agro-products & State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Zhejiang Academy of Agricultural Sciences Hangzhou Zhejiang 310021 People's Republic of China;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Escherichia coli; IncHI2; mcr-1; ST2705; Tn6330;

    机译：大肠杆菌;英寸;MCR-1;ST2705;TN6330;

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